Results 111 to 120 of about 3,213,924 (323)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Splines on Cayley graphs of the symmetric group
Forum of Mathematics, SigmaA spline is an assignment of polynomials to the vertices of a graph whose edges are labeled by ideals, where the difference of two polynomials labeling adjacent vertices must belong to the corresponding ideal. The set of splines forms a ring. We consider
Nathan R. T. Lesnevich
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Conditions ($S_q$) and ($G_q$) on graded rings
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2006 Let be a commutative noetherian gradedring. We study Serre's condition and Ischebeck-Auslander's conditionin the graduate case. Let be an integer, we characterize the -torsion freeness of graded modules on a -ring.
La Barbiera, M
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
On graded weakly $ J_{gr} $-semiprime submodules
AIMS MathematicsLet $ \Gamma $ be a group, $ \mathcal{A} $ be a $ \Gamma $-graded commutative ring with unity $ 1, $ and $ \mathcal{D} $ a graded $ \mathcal{A} $-module.
Malak Alnimer +2 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Derived equivalences of upper-triangular ring spectra via lax limits
Comptes Rendus. MathématiqueWe extend a theorem of Ladkani concerning derived equivalences between upper-triangular matrix rings to ring spectra. Our result also extends an analogous theorem of Maycock for differential graded algebras.
Jasso, Gustavo
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source