Results 111 to 120 of about 903,684 (295)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Conditions ($S_q$) and ($G_q$) on graded rings

open access: yesAtti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2006
Let be a commutative noetherian gradedring. We study Serre's condition and Ischebeck-Auslander's conditionin the graduate case. Let be an integer, we characterize the -torsion freeness of graded modules on a -ring.
La Barbiera, M
doaj   +1 more source

Generalized rees rings and arithmetical graded rings

open access: yesJournal of Algebra, 1983
0. INTRODUCTION In this paper we study graded rings with an arithmetical ideal theory for the graded ideals, e.g., Gr-Dedekind and Gr-principal ideal rings. If these rings are positively graded rings, then the structure of Gr-Dedekind and of Gr-principal ideal rings is easily investigated and it is much like the structure of the ungraded equivalents ...
openaire   +2 more sources

The associated graded ring and the index of a Gorenstein local ring

open access: yes, 1994
Let ( R , m , k ) (R,\mathfrak {m},k) be a Gorenstein local ring. It is shown that if the associated graded ring G ( R ) G(R)
Songqing Ding
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Splines on Cayley graphs of the symmetric group

open access: yesForum of Mathematics, Sigma
A spline is an assignment of polynomials to the vertices of a graph whose edges are labeled by ideals, where the difference of two polynomials labeling adjacent vertices must belong to the corresponding ideal. The set of splines forms a ring. We consider
Nathan R. T. Lesnevich
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

The representation ring of the structure group of the relative Frobenius morphism [PDF]

open access: yes, 2010
Severitt M. The representation ring of the structure group of the relative Frobenius morphism.
Severitt, Markus
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Strongly homogeneous primary ideals in a graded ring

open access: yes
summary:Let $R=\bigoplus _{\alpha \in \Gamma } R_\alpha $ be a commutative ring graded by an arbitrary torsionless grading monoid $\Gamma $. We call a graded primary ideal $P$ of $R$ to be strongly homogeneous primary if $a P \subseteq b R$ or $b^n R ...
Guennach, Nassima   +3 more
core   +1 more source

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