Results 71 to 80 of about 90,989 (277)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Seminormal graded rings and weakly normal projective varieties

International Journal of Mathematics and Mathematical Sciences, 1985
This paper is concerned with the seminormality of reduced graded rings and the weak normality of projective varieties. One motivation for this investigation is the study of the procedure of blowing up a non-weakly normal variety along its conductor ideal.
John V. Leahy, Marie A. Vitulli
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Control subgroups and birational extensions of graded rings

International Journal of Mathematics and Mathematical Sciences, 1999
In this paper, we establish the relation between the concept of control subgroups and the class of graded birational algebras. Actually, we prove that if R=⊕σ∈GRσ is a strongly G-graded ring and H⊲G, then the embedding i:R(H)↪R, where R(H)=⊕σ∈HRσ, is a ...
Salah El Din S. Hussein
doaj   +1 more source

Semisimple Graded Rings

Izvestiya of Saratov University. New Series. Series: Mathematics. Mechanics. Informatics, 2013
Leo Tolstoy Tula State Pedagogical University, Russia, 300026, Tula, Lenina pr., 125, ibalaba@mail.ru, KrasnovaEN.ne@yandex.ruThegradedversionofWedderburn–Artintheoremisobtained.ItgivesdescriptionofsemisimpleG-gradedringforarbitrarygroupG.Homological classification of graded semisimple rings is given.Key words: graded rings, graded modules, semisimple ...
I. N. Balaba, E. N. Krasnova
openaire   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The graded annihilating submodule graph

AKCE International Journal of Graphs and Combinatorics
In this paper, we study the graded annihilating graph for submodules, representing graded submodules as vertices connected by edges following a specific pattern.
Mamoon Ahmed, Fida Moh’d
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source