Results 81 to 90 of about 11,543 (300)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Forum of Mathematics, Sigma, 2020 We introduce a notion of complexity of diagrams (and, in particular, of objects and morphisms) in an arbitrary category, as well as a notion of complexity of functors between categories equipped with complexity functions.
SAUGATA BASU, UMUT ISIK
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Graded rings and graded Grothendieck groups
, 2016 This study of graded rings includes the first systematic account of graded Grothendieck ...
Hazrat, Roozbeh +1 more
core
Rings of endomorphisms of semigroup-graded modules
, 1996 We analyze various types of endomorphism rings of graded modules over rings graded by finite semi-groups, and show connections between such rings and certain skew rings.
MENINI, Claudia, G. ABRAMS
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Journal of Algebra, 1984 A ring R is said to be a G\(E_ 2\)-ring if \(GL_ 2(R)\), the group of 2\(\times 2\) invertible matrices over R, is generated by elementary and diagonal matrices. The author obtains some necessary conditions for a graded domain to be a \(GE_ 2\)-ring. This gives rise to a number of interesting consequences. Amongst other things it is proved, for example,
openaire +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Homotopy theory of modules over diagrams of rings
Proceedings of the American Mathematical Society, Series B, 2014 Given a diagram of rings, one may consider the category of modules over them. We are interested in the homotopy theory of categories of this type: given a suitable diagram of model categories ℳ(𝓈) (as 𝓈 runs through the diagram ...
J. P. C. Greenlees, B. Shipley
doaj +1 more source