Results 101 to 110 of about 469,261 (297)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Electric Analog of Acoustic Black Hole with Functionally Graded Perforated Rings
AcousticsWave propagation along acoustic black hole waveguides (ABH) consisting of arrays of functionally graded perforated rings (FGPR) is investigated by developing their linearized electro-acoustic analog models.
Kayla Petrover, Amr Baz
doaj +1 more source
The graded structure of algebraic Cuntz-Pimsner rings
, 2020 The algebraic Cuntz-Pimsner rings are naturally $\mathbb{Z}$-graded rings that generalize both Leavitt path algebras and unperforated $\mathbb{Z}$-graded Steinberg algebras.
Lännström, Daniel +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Results in Engineeringthe effective ratio of transverse bending stiffness ( η ) is a key parameter in the modified conventional method for segments of large-diameter shield tunnel, and it significantly influences the internal forces of these segments.
Shi-ju Ma +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Injective generation for graded rings [PDF]
In this paper we investigate injective generation for graded rings. We first examine the relation between injective generation and graded injective generation for graded rings.
Psaroudakis, Chrysostomos +1 more
core +1 more source
Generalized rees rings and arithmetical graded rings
Journal of Algebra, 1983 0. INTRODUCTION In this paper we study graded rings with an arithmetical ideal theory for the graded ideals, e.g., Gr-Dedekind and Gr-principal ideal rings. If these rings are positively graded rings, then the structure of Gr-Dedekind and of Gr-principal ideal rings is easily investigated and it is much like the structure of the ungraded equivalents ...
openaire +2 more sources