Results 71 to 80 of about 90,465 (279)

The graded annihilating submodule graph

AKCE International Journal of Graphs and Combinatorics
In this paper, we study the graded annihilating graph for submodules, representing graded submodules as vertices connected by edges following a specific pattern.
Mamoon Ahmed, Fida Moh’d
doaj   +1 more source

Cohen-Macaulay modules and holonomic modules over filtered rings [PDF]

, 2007
We study Gorenstein dimension and grade of a module $M$ over a filtered ring whose assosiated graded ring is a commutative Noetherian ring. An equality or an inequality between these invariants of a filtered module and its associated graded module is the
Miyahara, Hiroki, Nishida, Kenji
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

CATEGORICAL COMPLEXITY

Forum of Mathematics, Sigma, 2020
We introduce a notion of complexity of diagrams (and, in particular, of objects and morphisms) in an arbitrary category, as well as a notion of complexity of functors between categories equipped with complexity functions.
SAUGATA BASU, UMUT ISIK
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Semisimple Graded Rings

Izvestiya of Saratov University. New Series. Series: Mathematics. Mechanics. Informatics, 2013
Leo Tolstoy Tula State Pedagogical University, Russia, 300026, Tula, Lenina pr., 125, ibalaba@mail.ru, KrasnovaEN.ne@yandex.ruThegradedversionofWedderburn–Artintheoremisobtained.ItgivesdescriptionofsemisimpleG-gradedringforarbitrarygroupG.Homological classification of graded semisimple rings is given.Key words: graded rings, graded modules, semisimple ...
I. N. Balaba, E. N. Krasnova
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Homotopy theory of modules over diagrams of rings

Proceedings of the American Mathematical Society, Series B, 2014
Given a diagram of rings, one may consider the category of modules over them. We are interested in the homotopy theory of categories of this type: given a suitable diagram of model categories ℳ(𝓈) (as 𝓈 runs through the diagram ...
J. P. C. Greenlees, B. Shipley
doaj   +1 more source