Results 111 to 120 of about 3,311,038 (365)
Journal of the Mechanical Behavior of Materials, 2016 The gradient plasticity theory proposed by Aifantis and coworkers has been successfully used to model size effect phenomena at the microscale and nanoscale, by introducing into the formulation an internal length scale associated with the phenomenological
Wei Xiaokun +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Infinitely many radial solutions of superlinear elliptic problems with dependence on the gradient terms in an annulus [PDF]
, 2023 Yan Zhu, Ruyun Ma, Xiaoxiao Su
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On the strain gradient bending deformations
Journal of the Mechanical Behavior of Materials, 2013 Bending deformations are reviewed in the context of strain gradient linear elasticity, considering the complete set of strain gradient components. It is well understood that conventional bending deformations depend on the collective uniaxial extension of
Lazopoulos Konstantinos A. +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The social gradient in smoking: individual behaviour, norms and nicotine dependence in the later stages of the cigarette epidemic [PDF]
, 2021 Olof Östergren
openalex +1 more source
Primary arm spacing in chill block melt spun Ni-Mo alloys [PDF]
Chill block melt spun ribbons of Ni-Mo binary alloys containing 8.0 to 41.8 wt % Mo have been prepared under carefully controlled processing conditions.
Glasgow, T. K., Tewari, S. N.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Nonlinear Robin problems with unilateral constraints and dependence on the gradient
Electronic Journal of Differential Equations, 2018 We consider a nonlinear Robin problem driven by the p-Laplacian, with unilateral constraints and a reaction term depending also on the gradient (convection term). Using a topological approach based on fixed point theory (the Leray-Schauder alternative
Nikolaos S. Papageorgiou +2 more
doaj