Results 101 to 110 of about 1,712,958 (251)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Nonlinear Robin problems with unilateral constraints and dependence on the gradient
Electronic Journal of Differential Equations, 2018 We consider a nonlinear Robin problem driven by the p-Laplacian, with unilateral constraints and a reaction term depending also on the gradient (convection term). Using a topological approach based on fixed point theory (the Leray-Schauder alternative
Nikolaos S. Papageorgiou +2 more
doaj
On 'spot' evolution under an adverse pressure gradient [PDF]
, 2001 The unsteady travelling 'spots' or spot-like disturbances are produced, in an otherwise planar boundary layer, by an initial impulse/blip, from wall forcing or from nearby external forcing. Theory and computations are described for the evolving spot-like
Timoshin, SN, Smith, FT
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FARADAY MAGNETOMETER WITH SHERIC POLE PIECES: IDENTIFICATION ZONE WITH A STABLE FORCE FACTOR
Российский технологический журнал, 2017 Basic principles and approaches in generation of devices for realization Faraday method are evaluated (for learning magnetic susceptibility of samples). It is noticed that problem exists - it is difficult to identify an operating area to coordinate here ...
A. V. Sandulyak +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Non-local gradient dependent operators
Advances in Mathematics, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bjorland, C. +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Journal of the Mechanical Behavior of Materials, 2016 The gradient plasticity theory proposed by Aifantis and coworkers has been successfully used to model size effect phenomena at the microscale and nanoscale, by introducing into the formulation an internal length scale associated with the phenomenological
Wei Xiaokun +3 more
doaj +1 more source
Figure 3: Path-Gradient-Planning - Allocentric Gradient Norms
Path-Gradient Norms for Grid-world environments show in Figure 1.E-OEach frame represents the heat-map of gradient norms for each state over training steps.
Francesco Trapani (16642515)
core +1 more source