Results 81 to 90 of about 1,712,958 (251)

Partial dependence plots of the relationships between probability of high GDM severity on leaves and the four most important climate variables of gradient boosting (according to Fig 5D).

open access: yes, 2020
Each graph represents the marginal effect of one variable on the probability computed by the gradient boosting model. (A) Partial dependence plot for the average amount of rainfall in May (in mm/day). (B) Partial dependence plot for the average amount of
François Brun (8566476)   +3 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Mesh-dependence of Material with Softening Behavior

open access: yes, 2010
The issue of mesh-dependence emerges when the conventional continuum damage model is applied to handling the softening behavior. In order to circumvent the mesh-dependence, the non-local theory is introduced into the conventional damage model and the ...
Xingwen, Du, Li, Fu
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Calcium Gradient Dependent Pyrophosphate Formation by Sarcoplasmic Vesicles

open access: yesZeitschrift für Naturforschung C, 1977
Abstract Pyrophosphate Synthesis, Sarcoplasmic Reticulum, Calcium Accumulation The vesicles of the sarcoplasmic membranes synthesize pyrophosphate from inorganic phosphate. Pyrophosphate synthesis proceeds as long as a calcium gradient is maintained across the vesicular membranes.
Hasselbach, W., Migala, A.
openaire   +3 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Model1-gradient-PSG-GN

open access: yes, 2023
 The gradient distribution of PSG-GN inversion. The data can use Tecplot to load and draw figures. 
Xiuyan Ren (14583824)
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Hyper-dependence, hyper-ageing properties and analogies between them: a semigroup-based approach [PDF]

open access: yes, 2001
In previous papers, evolution of dependence and ageing, for vectors of non-negative random variables, have been separately considered. Some analogies between the two evolutions emerge however in those studies.
SPIZZICHINO, Fabio   +4 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

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