Results 61 to 70 of about 1,712,958 (251)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Synthetic Oversampling Method Based Noiseless Gradient Distribution [PDF]
Jisuanji kexueSynthetic Oversampling Method is an important means to solve imbalanced classification problem,but the current oversampling methods still have many problems when dealing with high-dimensional imbalanced classification problem.A synthetic oversampling ...
HU Libin, ZHANG Yunfeng, LIU Peide
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Atomistic simulations of plasticity heterogeneity in gradient nano-grained FCC metals
Materials & Design, 2022 Gradient nano-grained (GNG) metals are an emerging class of heterogeneous structured materials with extraordinary mechanistic performances and unnatural plasticity mechanisms, which are unachievable in traditional homogeneous nanocrystalline metals. Here,
Like Xu +3 more
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Four simplified gradient elasticity models for the simulation of dispersive wave propagation [PDF]
, 2008 Gradient elasticity theories can be used to simulate dispersive wave propagation as it occurs in heterogeneous materials. Compared to the second-order partial differential equations of classical elasticity, in its most general format gradient elasticity ...
Pichugin, AV +7 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Nodal solutions for Neumann systems with gradient dependence
Boundary Value ProblemsWe consider the following convective Neumann systems: ( S ) { − Δ p 1 u 1 + | ∇ u 1 | p 1 u 1 + δ 1 = f 1 ( x , u 1 , u 2 , ∇ u 1 , ∇ u 2 ) in Ω , − Δ p 2 u 2 + | ∇ u 2 | p 2 u 2 + δ 2 = f 2 ( x , u 1 , u 2 , ∇ u 1 , ∇ u 2 ) in Ω , | ∇ u 1 | p 1 − 2 ...
Kamel Saoudi +2 more
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Resonant optical gradient force interaction for nano-imaging and -spectroscopy
New Journal of Physics, 2016 The optical gradient force provides optomechanical interactions, for particle trapping and manipulation, as well as for near-field optical imaging in scanning probe microscopy.
Honghua U Yang, Markus B Raschke
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Boundary Value Problems, 2020 In our paper we address the thermoelasticity theory of the strain gradient. First, we define the mixed problem with initial and boundary data in this context.
Marin Marin, Sorin Vlase, Ioan Tuns
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Dispersive properties of gradient-dependent and rate-dependent media
Mechanics of Materials, 1994 The dispersive behaviour of waves propagating in gradient-dependent and rate-dependent media is investigated analytically and numerically. Attention is focused on the proper modelling of dynamic strain localisation and the crucial role that dispersion plays in this.
Sluys, L.J., Borst, de, R.
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source