Results 41 to 50 of about 192,182 (265)

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia   +6 more
wiley   +1 more source

Solvability of quasilinear elliptic equations with strong dependence on the gradient

open access: yesAbstract and Applied Analysis, 2000
We study the problem of existence of positive, spherically symmetric strong solutions of quasilinear elliptic equations involving p-Laplacian in the ball. We allow simultaneous strong dependence of the right-hand side on both the unknown function and its
Darko Žubrinić
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean   +7 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Nonzero Positive Solutions of Elliptic Systems with Gradient Dependence and Functional BCs

open access: yesAdvanced Nonlinear Studies, 2020
We discuss, by topological methods, the solvability of systems of second-order elliptic differential equations subject to functional boundary conditions under the presence of gradient terms in the nonlinearities.
Biagi Stefano   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dispersive properties of gradient-dependent and rate-dependent media

open access: yesMechanics of Materials, 1994
The dispersive behaviour of waves propagating in gradient-dependent and rate-dependent media is investigated analytically and numerically. Attention is focused on the proper modelling of dynamic strain localisation and the crucial role that dispersion plays in this.
Sluys, L.J., Borst, de, R.
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Synthetic Oversampling Method Based Noiseless Gradient Distribution [PDF]

open access: yesJisuanji kexue
Synthetic Oversampling Method is an important means to solve imbalanced classification problem,but the current oversampling methods still have many problems when dealing with high-dimensional imbalanced classification problem.A synthetic oversampling ...
HU Libin, ZHANG Yunfeng, LIU Peide
doaj   +1 more source

Atomistic simulations of plasticity heterogeneity in gradient nano-grained FCC metals

open access: yesMaterials & Design, 2022
Gradient nano-grained (GNG) metals are an emerging class of heterogeneous structured materials with extraordinary mechanistic performances and unnatural plasticity mechanisms, which are unachievable in traditional homogeneous nanocrystalline metals. Here,
Like Xu   +3 more
doaj   +1 more source

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