Results 121 to 130 of about 3,703,082 (328)
Nonlinear Robin problems with unilateral constraints and dependence on the gradient
Electronic Journal of Differential Equations, 2018 We consider a nonlinear Robin problem driven by the p-Laplacian, with unilateral constraints and a reaction term depending also on the gradient (convection term). Using a topological approach based on fixed point theory (the Leray-Schauder alternative
Nikolaos S. Papageorgiou +2 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Primary arm spacing in chill block melt spun Ni-Mo alloys [PDF]
Chill block melt spun ribbons of Ni-Mo binary alloys containing 8.0 to 41.8 wt % Mo have been prepared under carefully controlled processing conditions.
Glasgow, T. K., Tewari, S. N.
core +1 more source
Limit theorems for gradient-dependent elastoplastic geomaterials
International Journal of Solids and Structures, 2007 AbstractIn this paper, the limit theorems proposed by Drucker and co-workers are reformulated to address a class of gradient-dependent elastoplastic geomaterials. The gradient effects are accounted for by incorporating strain gradients and their conjugate higher-order stresses into the constitutive descriptions. Gradient-dependent equilibrium equations
Zhao, Jidong +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
DESTRUCTION OF FERROMAGNETIG MATERIAL PARTICLES IN MAGNETOVIBRATING LAYER WITH HIGH POROSITY
Advanced Engineering Research, 2011 The dependence of fineness ratio of magnetic material powders in the magnetovibrating layer on the gradient of magnetic field induction is analyzed.
Yury M. Vernigorov, Natalia N. Frolova
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
DESTRUCTION OF FERROMAGNETIG MATERIAL PARTICLES IN MAGNETOVIBRATING LAYER WITH HIGH POROSITY
Вестник Донского государственного технического университета, 2018 The dependence of fineness ratio of magnetic material powders in the magnetovibrating layer on the gradient of magnetic field induction is analyzed.
Yury M. Vernigorov, Natalia N. Frolova
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Indentation size effects in crystalline materials: A law for strain gradient plasticity
, 1998 We show that the indentation size effect for crystalline materials can be accurately modeled using the concept of geometrically necessary dislocations. The model leads to the following characteristic form for the depth dependence of the hardness: H H 0 1+
W. Nix, Huajian Gao
semanticscholar +1 more source