Results 51 to 60 of about 2,575,606 (330)
Hydraulic Analysis of Water Distribution Networks Based on the Gradient Matrix Form and Comparing it with Other Conventional Methods [PDF]
مهندسی منابع آب, 2014 Hydraulic analysis of water networks consists of determination of the discharge rate in each pipe and the piezometric head at nodes. Benefiting from the matrices algebra, and developing equations following the Taylor series, the gradient method ...
M. H, S. R, S.M N
doaj
Geometrical Inverse Preconditioning for Symmetric Positive Definite Matrices
Mathematics, 2016 We focus on inverse preconditioners based on minimizing F ( X ) = 1 − cos ( X A , I ) , where X A is the preconditioned matrix and A is symmetric and positive definite. We present and analyze gradient-type methods to minimize F ( X )
Jean-Paul Chehab, Marcos Raydan
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Analysis and Synthesis in the Design of Magnetic Switching Electric Machines
Actuators, 2021 A systematic approach to the design of electrical machines is implemented by solving problems of analysis and synthesis in various combinations at different stages and stages of design. The questions of the formulation and implementation of synthesis and
Nikolay Shaitor +2 more
doaj +1 more source
A Robust Adaptive Stochastic Gradient Method for Deep Learning
, 2017 Stochastic gradient algorithms are the main focus of large-scale optimization problems and led to important successes in the recent advancement of the deep learning algorithms. The convergence of SGD depends on the careful choice of learning rate and the
Bengio, Yoshua +3 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
An Accelerated Proximal Coordinate Gradient Method and its Application to Regularized Empirical Risk Minimization [PDF]
, 2014 We consider the problem of minimizing the sum of two convex functions: one is smooth and given by a gradient oracle, and the other is separable over blocks of coordinates and has a simple known structure over each block.
Lin, Qihang, Lu, Zhaosong, Xiao, Lin
core +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Comparison the readings of gravity field and it‘s gradient potential
Қарағанды университетінің хабаршысы. Математика сериясы, 2019 The problem of studying the deep structure of the earth’s crust is one of the strategic directions of geophysical research, ensuring the development of Earth sciences.
М.О. Kenzhebayeva
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source