Results 61 to 70 of about 2,575,606 (330)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Applications of Mitscherlich Baule function: a robust regression approach

Research in Statistics
Consistent estimation techniques need to be implemented to obtain robust empirical outcomes which help policymakers formulating public policies. Therefore, Mitscherlich Baule function was implemented using robust regression model based on a growth ...
Rizwan Yousuf, Manish Sharma
doaj   +1 more source

Model Based Optimisation Algorithm for Maximum Power Point Tracking in Photovoltaic Panels

Energies, 2020
Extracting maximum energy from photovoltaic (PV) systems at varying conditions is crucial. It represents a problem that is being addressed by researchers who are using several techniques to obtain optimal outcomes in real-life scenarios.
Faiçal Hamidi, Severus Constantin Olteanu, Dumitru Popescu, Houssem Jerbi, Ingrid Dincă, Sondess Ben Aoun, Rabeh Abbassi   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A Novel Design Method of Gradient Porous Structure for Stabilized and Lightweight Mandibular Prosthesis [PDF]

, 2022
Renshun Liu, Yu‐Xiong Su, Wei‐fa Yang, Kai Wu, Ruxu Du, Yong Zhong   +5 more
openalex   +1 more source

Seasonal Analysis of Planetary Boundary Layer and Turbulence in Warsaw, Poland Through Lidar and LES Simulations

Remote Sensing
We analyzed the planetary boundary layer (PBL) characteristics in Warsaw, Poland for a day of summer, autumn, winter, and spring of 2021 by integrating and comparing measured and simulated data.
Rayonil G. Carneiro, Maciej Karasewicz, Camilla K. Borges, Lucja Janicka, Dongxiang Wang, Gilberto Fisch, Iwona S. Stachlewska   +6 more
doaj   +1 more source

Non-Uniform Stochastic Average Gradient Method for Training Conditional Random Fields [PDF]

, 2015
We apply stochastic average gradient (SAG) algorithms for training conditional random fields (CRFs). We describe a practical implementation that uses structure in the CRF gradient to reduce the memory requirement of this linearly-convergent stochastic ...
Ahmed, Mohamed Osama, Babanezhad, Reza, Clifton, Ann, Defazio, Aaron, Sarkar, Anoop, Schmidt, Mark   +5 more
core  

Accelerated Gradient Methods for Networked Optimization

, 2012
We develop multi-step gradient methods for network-constrained optimization of strongly convex functions with Lipschitz-continuous gradients. Given the topology of the underlying network and bounds on the Hessian of the objective function, we determine ...
Ghadimi, Euhanna, Johansson, Mikael, Shames, Iman   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source