Results 81 to 90 of about 36,010,976 (311)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Accounting for Round-Off Errors When Using Gradient Minimization Methods

Algorithms, 2022
This paper discusses a method for taking into account rounding errors when constructing a stopping criterion for the iterative process in gradient minimization methods.
Dmitry Lukyanenko, Valentin Shinkarev, Anatoly Yagola   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Accelerated Gradient Methods for Networked Optimization

, 2012
We develop multi-step gradient methods for network-constrained optimization of strongly convex functions with Lipschitz-continuous gradients. Given the topology of the underlying network and bounds on the Hessian of the objective function, we determine ...
Ghadimi, Euhanna, Johansson, Mikael, Shames, Iman   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Antimicrobial Susceptibility Testing to Erythromycin and Azithromycin of Clinical Isolates of Bordetella pertussis Circulating in Russia

Эпидемиология и вакцинопрофилактика
Relevance. Antibacterial drugs are widely used to treat and prevent infections of the upper and lower respiratory tract. The large-scale and unjustified use of antimicrobials to treat these infections has led to the emergence of resistance in most ...
A. S. Pimenova, N. T. Gadua, I. Yu. Andrievskaya, O. Yu. Borisova, M. S. Petrova, A. B. Borisova, S. S. Afanas'ev, I. V. Podoprigora, M. S. Afanas'ev, T. I. Moskvina, G. V. Vorob'eva, I. M. Degtyareva, O. V. Timirkina, S. A. Luk'yanceva, T. N. Trigorlova   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Rapid Identification Method for Concrete Defect Boundaries Based on Acoustic-Mode Gradient Analysis

Buildings
Concrete is extensively utilized in infrastructure projects. However, issues like construction quality and external loads can lead to the formation of thin-plate-like voids with considerable aspect ratios, posing serious safety risks and highlighting the
Yong Yang, Peixuan Shen, Ziming Qi, Shiqi Liu   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Numerical Solution of the Direct and Inverse Problems in the Gas Lift Process of Oil Production Using the Conjugate Equations Method

Applied System Innovation
This article considers the numerical solution of the direct and inverse problems of the gas lift process in oil production, described by a system of hyperbolic equations.
Nurlan M. Temirbekov, Amankeldy K. Turarov, Syrym E. Kasenov   +2 more
doaj   +1 more source