Results 91 to 100 of about 36,010,976 (311)

Non-Uniform Stochastic Average Gradient Method for Training Conditional Random Fields [PDF]

, 2015
We apply stochastic average gradient (SAG) algorithms for training conditional random fields (CRFs). We describe a practical implementation that uses structure in the CRF gradient to reduce the memory requirement of this linearly-convergent stochastic ...
Ahmed, Mohamed Osama, Babanezhad, Reza, Clifton, Ann, Defazio, Aaron, Sarkar, Anoop, Schmidt, Mark   +5 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Optical classification of images at different wavelengths using spectral diffractive neural networks

Компьютерная оптика
A solution of several different problems of image classification at several different wavelengths using a diffractive neural network (DNN) consisting of sequentially located phase diffractive optical elements (DOEs) is considered.
G.A. Motz, D.V. Soshikov, L.L. Doskolovich, E.V. Byzo, E.A. Bezus, D.A. Bykov   +5 more
doaj   +1 more source

Low Complexity Wireless Powered Information Transfer Strategy for Multiuser MIMO Systems

IEEE Access, 2018
In this paper, the minimum achievable rate maximization problem for wireless-powered multiple users is investigated. Zero-forcing (ZF)-based precoding is considered for information transmission (IT) in the uplink from multi-antenna users to a multi ...
Jihoon Choi, Jingon Joung
doaj   +1 more source

Design of generalized fractional order gradient descent method

, 2020
This paper focuses on the convergence problem of the emerging fractional order gradient descent method, and proposes three solutions to overcome the problem. In fact, the general fractional gradient method cannot converge to the real extreme point of the
Kang, Yu, Wang, Yong, Wei, Yiheng, Yin, Weidi   +3 more
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Application of Convective Condensation Level Limiter in Convective Boundary Layer Height Retrieval Based on Lidar Data

Atmosphere, 2017
Micro pulse lidar is a promising tool for retrieving the convective boundary layer height (CBLH), but its application has been hindered by sharp extinction of the signal in high humidity conditions, e.g., clouds. To remedy this, we developed an effective
Hong Li, Yi Yang, Xiao-Ming Hu, Zhongwei Huang, Guoyin Wang, Beidou Zhang   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source