Results 101 to 110 of about 2,146,103 (291)
Metals, 2018 Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are reported to vary the stiffness and make it comparable to cortical or trabecular bone.
Ezgi Onal +4 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Virtual and Physical PrototypingFunctionally graded materials (FGMs) have attracted significant interest due to their ability to tailor properties throughout the volume. However, achieving cross-scale structural regulation of FGMs, from macro to micro, is difficult using traditional ...
Jian-Xin Sun +8 more
doaj +1 more source
A Bramble-Pasciak conjugate gradient method for discrete Stokes equations with random viscosity
, 2018 We study the iterative solution of linear systems of equations arising from stochastic Galerkin finite element discretizations of saddle point problems. We focus on the Stokes model with random data parametrized by uniformly distributed random variables ...
Lang, Jens +2 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fabrication and mechanical properties of gradient-structured W–Ni–Fe–Mo/Co tungsten heavy alloys
Fenmo yejin jishuGradient-structured tungsten heavy alloys with spatially graded mechanical properties can effectively resolve the strength-ductility trade-off in conventional homogeneous tungsten alloys. The high-strength 93W–Ni–Fe–Mo alloys and high-ductility 90W–Ni–Fe–
MENG Ziqi +6 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Gradient solute cluster evolution and strengthening in a cyclic torsion-baked dilute Mg alloy
Materials Research LettersSolute clustering provides a promising route to overcome the strength-ductility trade-off, yet controlled formation of such clusters remains challenging in Mg alloys.
Zhangting Hu +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
CrystalsTitanium carbonitride (Ti(C,N))-based ceramics are widely utilized in mechanical machining, aerospace, and electronics, particularly in cutting tools and wear-resistant components.
Yunhao Zhang +5 more
doaj +1 more source