Results 71 to 80 of about 16,696,427 (330)
Journal of the American Medical Association (JAMA), 2018 Importance The optimal temporal approach for reducing nicotine to minimally or nonaddictive levels in all cigarettes sold in the United States has not been determined.
Dorothy K. Hatsukami +27 more
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2019 Session types are a rich type discipline, based on linear types, that lifts the sort of safety claims that come with type systems to communications. However, web-based applications and microservices are often written in a mix of languages, with type ...
VASCO T. VASCONCELOS +10 more
core +1 more source
, 2016 According to literature, oil price shocks and volatility can have sector-specific impacts in the market. While these studies include most asset groups, the dynamic relationship between the oil market and Real Estate Investment Trusts (REITs) has not been
Ş. Nazlıoğlu, N. Gormus, U. Soytaş
semanticscholar +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A gradual interpretation of union types [PDF]
, 2017 Union types allow to capture the possibility of a term to be ofseveral possibly unrelated types. Traditional static approaches to uniontypes are untagged and tagged unions, which present dual advantagesin their use.
Tanter, Éric +3 more
core +1 more source
BioengineeringRadiofrequency ablation (RFA) is a pivotal therapeutic technique for various medical conditions, including cardiovascular disease and oncological conditions such as liver and lung cancer.
Cheol-Min Lee +3 more
doaj +1 more source
Journal of Cardiothoracic Surgery, 2017 Background Early detection of respiratory overload is crucial to mechanically ventilated patients, especially during phases of spontaneous breathing. Although a diversity of methods and indices has been established, there is no highly specific approach ...
Thomas Breuer +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source