Results 81 to 90 of about 1,705,978 (427)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Needs Assessment in Postgraduate Medical Education:A Review [PDF]

, 2002
Although the concept of needs assessment in continuing medical education is well accepted, there is limited information on needs assessment in postgraduate medical education.
Hilliard MD, EdD, Robert, Ratnapalan MBBS, Savithiri   +1 more
core  

Dynamics and Statistical Mechanics of Closed Composite Multi-Level University and Scientific Hierarchical Systems Pertaining to the Undergraduate and Graduate Student Phenomena [PDF]

arXiv, 2021
Content: Qualitative and ad-hoc descriptions of observations of the "undergraduate" and "graduate" effects. Comparisons between the classical models of both undergraduate and graduate systems separately lead to the conclusion that a quantized model is inevitably required to explain certain effects such as "Spooky Action At A Seminar" and the FTR (Food ...
arxiv  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Association of Gender With Learner Assessment in Graduate Medical Education

JAMA Network Open, 2020
This cross-sectional study evaluates the association of gender with assessment of internal medicine residents.
Robin Klein, Nneka N. Ufere, Sowmya R. Rao, J. Koch, Anna Volerman, E. Snyder, S. Schaeffer, V. Thompson, A. S. Warner, Katherine A Julian, Kerri Palamara   +10 more
semanticscholar   +1 more source

Graduate Medical Education (GME) Showcase Portfolio Assessment

MedEdPORTAL, 2006
Introduction Presently, a nationwide effort by residency education programs to more objectively assess and document resident performance within the ACGME General Competencies is in progress.
Robert Jarvis
doaj   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Leadership Training in Graduate Medical Education: A Systematic Review.

Journal of Graduate Medical Education, 2018
Background Leadership is a critical component of physician competence, yet the best approaches for developing leadership skills for physicians in training remain undefined.
Brett W. Sadowski, S. Cantrell, Adam Barelski, P. O'Malley, Joshua D. Hartzell   +4 more
semanticscholar   +1 more source

Pipeline Programs [PDF]

, 2017
Pipeline programs are designed to prepare and inspire students to pursue careers in medicine and medical research. SKMC is committed to providing experiences and education to middle school, high school, college, and graduate students from groups ...

core   +1 more source