Results 31 to 40 of about 644,974 (304)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Research mentorship in graduate programs in a developing country: An ethical perspective

Social Sciences and Humanities Open
Avoidance of research misconduct, authorship conflict, and adequate research training, including research ethics, is essential for high-quality research outcomes.
Samer F. Swedan, Karem H. Alzoubi, Omar F. Khabour, Alaa A.A. Aljabali, Manal Hendawi, Wael K. Al-Delaimy   +5 more
doaj   +1 more source

An Evaluation of the Transition Process from Teaching to the Academia

International Journal of Contemporary Educational Research, 2018
The recent increase in the number of universities in Turkey has speeded up the transition of teachers who receive graduate education to the academia. However, this rapid transition brought a variety of problems.
Abdullah Balıkçı, Ramazan Cansoy, Hanifi Parlar   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Kur’an Araştırmalarında Akademik Tezler-Batı ve İslam Dünyası Mukayesesi (Uluslararası Sempozyum, İstanbul 24-26 Kasım 2017)

Cumhuriyet İlahiyat Dergisi, 2017
Türkiye’de lisansüstü eğitim son yıllarda çeşitli ortamlarda inceleme, değerlendirme ve eleştirilere konu olmaktadır. Bunun son örneği 24-26 Kasım 2016’da İstanbul’da yapılan uluslararası bilimsel bir toplantı idi.
İsmail Çalışkan
doaj  

Competency-based medical education: How far, how much

Journal of Family Medicine and Primary Care, 2019
Competency-based medical education inscribed in the Graduate Medical Education Regulations from Medical Council of India is cogently grounded by the Curriculum Implementation Support Programme throughout the country under the aegis of Medical Education ...
Amrita Ghosh, Ranabir Pal, Raman Kumar
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Growing a Specialty Specific Community of Practice in Education Scholarship

Western Journal of Emergency Medicine, 2015
Emergency medicine (EM) educators have many masters. These include our hospital administrations who expect efficient patient care reflecting the priorities of safety and quality, the accreditation council for graduate medical education which has ...
Jeffrey N. Love, Douglas S. Ander
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source