Results 31 to 40 of about 259,040 (314)

A comparison of the nursing competence of graduates and diplomates from UK nursing programmes

, 2000
This paper reviews the literature on nursing competence measurement and reports the results of a comparative quantitative study of the competencies of Project 2000 diplomates and BA (Hons) Adult Nursing graduates from two UK nursing programmes.
Taylor, H.R., Bartlett, H.P., Westcott, E., Simonite, V.   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats

Scientific Reports
Schizophrenia is a neuropsychiatric disorder with limited treatment options that have unwanted side effects. Clozapine, an atypical antipsychotic, has been used for resistant schizophrenia.
Mina Y. George, Nermeen Farag, Esther T. Menze, Reham S. Elezaby, Nayera A. Salem, Shereen K. Elrahmany, Nahed Adel, Rana M. ElKhatib, Menna Galal, Hams Assem, Radwa Elkhouly, Mariam Alkess Wesa, Noha Hesham, Nouran Hossam, Iriny M. Ayoub   +14 more
doaj   +1 more source

A Case of Nonfunctioning Pituitary Carcinoma That Responded to Temozolomide Treatment

Case Reports in Endocrinology, 2012
Pituitary carcinoma is a rare malignancy and is difficult to manage. Pituitary carcinomas commonly produce either PRL or ACTH, but some do not produce pituitary hormones.
Haruko Morokuma, Takao Ando, Takuya Hayashida, Ichiro Horie, Naoko Inoshita, Fumi Murata, Ikuko Ueki, Kan Nakamura, Misa Imaizumi, Toshiro Usa, Atsushi Kawakami   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The relationship between adverse childhood experience, resilience, and psychosocial well-being among undergraduates in Osun State, Nigeria

BMC Psychology
Background Adverse childhood experiences (ACEs) are potentially traumatic events that are associated with negative outcomes, which may contribute to a life course trajectory that connects early adversity with long-term adult health issues.
Anuoluwapo Precious Opadele, Bisola Odunayo Alabi, Oyindamola Bolorunduro, Bukola Emilola Olorunfemi, Oyindamola Ayoola, Temidayo Akinreni, Oladayo Akinwale Damilola, Olayinka Ajao, Ifedola Olabisi Faramade, Akinlolu Omisore   +9 more
doaj   +1 more source

Global research trends and hotspots analysis of hallux valgus: A bibliometric analysis from 2004 to 2021

Frontiers in Surgery, 2023
BackgroundHallux valgus (HV) is a common foot and ankle surgery disease. The correction of HV deformity relies on a highly challenging surgical treatment.
Shulong Wang, Shulong Wang, Ping Deng, Ping Deng, Xiaojie Sun, Xiaojie Sun, Jinglu Han, Jinglu Han, Shanshan Yang, Zhaojun Chen   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives

Frontiers in Immunology
ObjectiveThe objective of this study is to conduct a bibliometric analysis on examining the current condition, areas of interest, and rising trends of immunotherapy for osteosarcoma (ITFOS), as well as its importance in associated research domains ...
Yunxiang Hu, Yunxiang Hu, Rui Yang, Shuai Ni, Shuai Ni, Zefeng Song   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source