Results 61 to 70 of about 1,067,912 (306)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A study of flavonoid inhibitors against Monkeypox H1 phosphatase

Journal of Enzyme Inhibition and Medicinal Chemistry
Poxviruses regulate their replication cycle through host phosphorylation pathways, with dual-specific phosphatase H1(DUSP-H1) playing a key role in immune evasion by dephosphorylating STAT1 and inhibiting interferon(IFN) responses.
Hwa Young Kim, Mi-Sun Kim, Dong Hae Shin
doaj   +1 more source

Storage stability of anti-Salmonella Typhimurium immunoglobulin Y in immunized quail eggs stored at 4°C

Indian Journal of Animal Sciences, 2020
Chicken egg yolk antibodies (IgYs) are extensively used for immunotherapy and immunodiagnostic purposes. Oral immunotherapy with specific IgYs is established as an efficient alternative to traditional antibiotic therapy in human and animals.
ATEFEH ESMAILNEJAD, BAHMAN ABDI HACHESOO, ELHAMSADAT HOSSEINI NASAB, MARYAM SHAKOORI   +3 more
doaj   +1 more source

Entrepreneurship and UK doctoral graduates [PDF]

, 2011
Copyright c 2011 IP Publishing Ltd. Reproduced by permissionThis paper discusses the experience of UK doctoral graduates in pursuing entrepreneurial careers: there is evidence that this applies to a substantial number - about 10% - of doctoral graduates.
Bentley, Kieran, Hooley, Tristram, Marriott, John   +2 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Student Debt and the Class of 2007 [PDF]

, 2008
Analyzes state-by-state trends in the average debt of 2007 graduates and percentages of graduates with debt. Lists high- and low-debt states and campuses.
Matthew Reed
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Indian Foreign Policy towards Pakistan during Modi Era: Assessing the Role of Ideology - Hindu Nationalism

BTTN Journal, 2022
Foreign policy conduct of a State, executed by its leaders, broadly reflects various patterns of its experiences, beliefs and policies. Domestic factors coupled with systemic pressures play an important role in shaping states’ behavior.
Adeela Azam
doaj  

Minimization of maximum amplitude magnification factor in designing double-mass dynamic vibration absorbers (Application of optimality criteria method to parallel and series types)

Nihon Kikai Gakkai ronbunshu, 2017
The optimal design method of double-mass dynamic vibration absorbers (DVAs) is discussed with respect to the minimization of the maximum amplitude magnification factor.
Osamu NISHIHARA
doaj   +1 more source

Blending arts and sciences: gimmick or necessity? [PDF]

, 2008
The shortage of degree qualified engineers in the UK is well documented. On the other hand the surplus of art and design graduates is growing. Whilst acknowledging the shortage in engineering graduates, there is also the need to recognise the breadth and
Bradley, Michael D., Karamanoglu, Mehmet, Prior, Stephen D.   +2 more
core