Results 71 to 80 of about 332,330 (302)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Nuclear factor-κ B inducing kinase is required for graft-versus-host disease

Haematologica, 2010
Background Donor T lymphocytes are directly responsible for graft-versus-host disease. Molecules important in T-cell function may, therefore, be appropriate targets for graft-versus-host disease therapy and/or prophylaxis.
Carmen Sánchez-Valdepeñas, Lucía Casanova, Isabel Colmenero, Mar Arriero, África González, Nieves Lozano, Marta González-Vicent, Miguel A. Díaz, Luís Madero, Manuel Fresno, Manuel Ramírez   +10 more
doaj   +1 more source

Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation

, 2012
Chronic graft-versus-host disease (cGVHD) is a complication after minor antigen mismatched bone marrow transplantation (BMT) characterized by an autoimmune-type reaction in various organs.
Yumi Matsuzaki, Yoko Ogawa, Shigeto Shimmura, Yo Mabuchi, Sadafumi Suzuki, Yutaka Kawakami, Shinichiro Okamoto, Hideyuki Okano, Takaaki Inaba, Satoru Morikawa, Saori Yaguchi, Kazuo Tsubota, Tomonori Yaguchi   +12 more
core  

Backgrounds of patients with acute gastrointestinal graft-versus-host disease or infectious colitis.

, 2018
Backgrounds of patients with acute gastrointestinal graft-versus-host disease or infectious colitis.
Gota Sudo (5570936), Daisuke Hirayama (4396837), Tomoya Iida (4732995), Toshiyuki Kubo (5570939), Masanori Nojima (52788), Hiroo Yamano (5570942), Kentaro Yamashita (796584), Hiroshi Nakase (783451), Sae Ohwada (5570933)   +8 more
core   +1 more source

Intestinal graft-versus-host disease [PDF]

Pediatric Radiology, 2010
A 17-month-old boy with acute lymphoblastic leukemia status 61 days post cord blood transplant presented with vomiting, diarrhea and feeding intolerance. Fluoroscopic examination with barium demonstrates diffuse narrowing of the small bowel lumen referred to as toothpasteor ribbon-like (Fig.
openaire   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Female genital tract chronic graft-versus-host disease: A narrative review

Hematology, Transfusion and Cell Therapy, 2019
Graft-versus-host disease is one of the main causes of morbidity and mortality in patients submitted to hematopoietic stem cell transplantation. This study reviewed the prevalence of lower female genital tract graft-versus-host disease following ...
Andréa Maria Novaes Machado, Nelson Hamerschlak, Morgani Rodrigues, Carla de Azevedo Piccinato, Sergio Podgaec, Lenira Maria Queiroz Mauad   +5 more
doaj   +1 more source

Lower gastrointestinal endoscopic findings in patients with acute gastrointestinal graft-versus-host disease or infectious colitis.

, 2018
Lower gastrointestinal endoscopic findings in patients with acute gastrointestinal graft-versus-host disease or infectious colitis.
Gota Sudo (5570936), Daisuke Hirayama (4396837), Tomoya Iida (4732995), Toshiyuki Kubo (5570939), Masanori Nojima (52788), Hiroo Yamano (5570942), Kentaro Yamashita (796584), Hiroshi Nakase (783451), Sae Ohwada (5570933)   +8 more
core   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source