Results 81 to 90 of about 7,285,650 (306)

Acute graft versus host disease

Orphanet Journal of Rare Diseases, 2007
Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins
Vogelsang Georgia B, Jacobsohn David A
doaj   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Graft-versus-host disease management

Bratislava Medical Journal, 2016
Graft-versus-host disease (GVHD) remains a major problem of allogeneic hematopoietic-stem cell transplantation (HSCT) and an obstacle for successful outcome. Clinically significant acute GVHD (grade II or higher) developed in 20 to 65 percent of the patients.
M, Mistrik, E, Bojtarova, L, Sopko, L, Masakova, L, Roziakova, J, Martinka, A, Batorova   +6 more
openaire   +3 more sources

Sensitivity of changes in chronic graft-versus-host disease activity to changes in patient-reported quality of life: results from the Chronic Graft-versus-Host Disease Consortium

Haematologica, 2011
Background The 2005 National Institute of Health Chronic Graft-versus-Host Disease Consensus Conference recommended collection of patient-reported outcomes in clinical trials on chronic graft-versus-host disease.
Joseph Pidala, Brenda F. Kurland, Xiaoyu Chai, Georgia Vogelsang, Daniel J. Weisdorf, Steven Pavletic, Corey Cutler, Navneet Majhail, Stephanie J. Lee   +8 more
doaj   +1 more source

Akut Graft versus Host Hastalığı

, 2019
Akut Graft vs. Host Hastalığı (GVHH); donör immun hücrelerin, konak (host) dokular üzerinde yarattığı reaksiyondur. Süreç; donörün aktive T hücrelerinin, inflamatuar bir kaskad ile konak epitelyal hücrelerine zarar vermesiyle oluşmaktadır.
Erkman Sanrı
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Nuclear factor-κ B inducing kinase is required for graft-versus-host disease

Haematologica, 2010
Background Donor T lymphocytes are directly responsible for graft-versus-host disease. Molecules important in T-cell function may, therefore, be appropriate targets for graft-versus-host disease therapy and/or prophylaxis.
Carmen Sánchez-Valdepeñas, Lucía Casanova, Isabel Colmenero, Mar Arriero, África González, Nieves Lozano, Marta González-Vicent, Miguel A. Díaz, Luís Madero, Manuel Fresno, Manuel Ramírez   +10 more
doaj   +1 more source

Backgrounds of patients with acute gastrointestinal graft-versus-host disease or infectious colitis.

, 2018
Backgrounds of patients with acute gastrointestinal graft-versus-host disease or infectious colitis.
Gota Sudo (5570936), Daisuke Hirayama (4396837), Tomoya Iida (4732995), Toshiyuki Kubo (5570939), Masanori Nojima (52788), Hiroo Yamano (5570942), Kentaro Yamashita (796584), Hiroshi Nakase (783451), Sae Ohwada (5570933)   +8 more
core   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source