Results 81 to 90 of about 179,002 (365)

Ocular Graft versus Host Disease

Vision Pan-America, 2015
Allogeneic hematopoietic stem cell transplantation is considered the standard of care for hematological and lymphoid malignancies. One of the complications associated to this therapy is an immune-mediated reaction known as graft versus host disease with ...
Paulo E.C. Dantas
doaj   +1 more source

Alloreactivity: the Janus-face of hematopoietic stem cell transplantation [PDF]

, 2017
Differences in major and minor histocompatibility antigens between donor and recipient trigger powerful graft-versus-host reactions after allogeneic hematopoietic stem cell transplantation (HSCT).
Apperley, J. (Jane), Brand, R. (René), Cornelissen, J.J. (Jan), Dreger, P. (Peter), Duarte, R.F. (Rafael), Gratwohl, A. (Alois), Greinix, H.T. (H. T.), Kroeger, N. (Nicolaus), Lanza, F. (F.), Mc Grath, E. (E.), Nagler, A. (Arnon), Niederwieser, D. (Dietger), Snowden, J. (John), Sureda, A. (Anna)   +13 more
core   +1 more source

Biofilm Control by Active Topography with Mucin Coating

Advanced Functional Materials, EarlyView.
This study reports a new antifouling strategy based on a bioinspired design. Mucin coating enhances biofilm control by active topography with beating micron‐sized pillars. Besides the mechanical force of beating pillars, the antibiofilm activities also involve biological factors since mucin coating inhibits swarming motility and c‐di‐GMP synthesis in ...
Zehui Han, Yikang Xu, Huan Gu, Teng Zhang, Dacheng Ren   +4 more
wiley   +1 more source

Sensitivity of changes in chronic graft-versus-host disease activity to changes in patient-reported quality of life: results from the Chronic Graft-versus-Host Disease Consortium

Haematologica, 2011
Background The 2005 National Institute of Health Chronic Graft-versus-Host Disease Consensus Conference recommended collection of patient-reported outcomes in clinical trials on chronic graft-versus-host disease.
Joseph Pidala, Brenda F. Kurland, Xiaoyu Chai, Georgia Vogelsang, Daniel J. Weisdorf, Steven Pavletic, Corey Cutler, Navneet Majhail, Stephanie J. Lee   +8 more
doaj   +1 more source

DomainScope: A disease network based on protein domain connections [PDF]

arXiv, 2019
Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv  

Biomarkers in graft versus host disease after allogeneic hematopoietic stem cell transplant [PDF]

, 2016
Hematopoietic stem cell transplant was developed as a curative therapy to treat onco-hematological diseases and recently indications for this therapy have expanded to include solid tumors, hemoglobinopathies and other genetic diseases and disorders.
Geary, Joshua J.
core   +1 more source

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

Advanced Functional Materials, EarlyView.
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen, Andreas B. Pedersen, Mireia Casanovas Montasell, Søren Moesgaard, Anja Bille Bohn, Alexander N. Zelikin   +5 more
wiley   +1 more source

Nuclear factor-κ B inducing kinase is required for graft-versus-host disease

Haematologica, 2010
Background Donor T lymphocytes are directly responsible for graft-versus-host disease. Molecules important in T-cell function may, therefore, be appropriate targets for graft-versus-host disease therapy and/or prophylaxis.
Carmen Sánchez-Valdepeñas, Lucía Casanova, Isabel Colmenero, Mar Arriero, África González, Nieves Lozano, Marta González-Vicent, Miguel A. Díaz, Luís Madero, Manuel Fresno, Manuel Ramírez   +10 more
doaj   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Correlation-based Discovery of Disease Patterns for Syndromic Surveillance [PDF]

arXiv, 2021
Early outbreak detection is a key aspect in the containment of infectious diseases, as it enables the identification and isolation of infected individuals before the disease can spread to a larger population. Instead of detecting unexpected increases of infections by monitoring confirmed cases, syndromic surveillance aims at the detection of cases with
arxiv