Results 101 to 110 of about 7,425,127 (300)

Looking into nerve damage in the cornea

eLife, 2019
Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye.
Mihaela Gadjeva
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Progress in acute graft versus host disease

, 2007
Purpose of review The aim of this article is to highlight both experimental and clinical studies contributing to our present understanding of acute graft versus host disease. Recent findings New cellular players and new molecules in induction, modulation
Holler, Ernst
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Treatment of Severe Steroid-Refractory Acute-Graft-vs.-Host Disease With Mesenchymal Stem Cells–Single Center Experience

Frontiers in Bioengineering and Biotechnology, 2018
The most effective treatment of steroid refractory acute graft vs. host disease (aGvHD) is not yet established and mesenchymal stem cells (MSC) appear to be a promising therapy for the condition. We report single center case series of three patients, who
Maja Česen Mazič, Lenart Girandon, Miomir Kneževič, Simona L. Avčin, Janez Jazbec   +4 more
doaj   +1 more source

Ocular Graft versus Host Disease

, 2015
Allogeneic hematopoietic stem cell transplantation is considered the standard of care for hematological and lymphoid malignancies. One of the complications associated to this therapy is an immune-mediated reaction known as graft versus host disease with ...
Paulo E.C. Dantas
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Overcoming skin rejection in composite tissue allotransplantation [PDF]

, 2008
The application of composite tissue techniques is constrained by the susceptibility of skin to rejection. The aim of this thesis is to improve our understanding of skin rejection and find ways to avoid it, in order to enable expansion of the ...
Horner, B., Horner, R.
core  

Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation

, 2019
Pulmonary graft vs. host disease is a diverse and underestimated complication following allogenic hematopoietic stem cell transplantation. We aimed to compare the airway architecture with chronic lung allograft dysfunction post lung transplantation ...
Dubbeldam, Adriana, Schoemans, Helene, Vanaudenaerde, Bart B.M., Boone, Matthieu N., van Raemdonck, Dirk ML, Van Raemdonck, Dirk, McDonough, John E, Vanaudenaerde, Bart M, Boone, Matthieu M.N., Verleden, Stijn E., Verleden, Stijn E, Schoemans, Helene HM, Verschakelen, Johny, Van Hoorebeke, Luc, McDonough, John E., Weynand, Birgit, Vanaudenaerde, Bart M., Verleden, Geert, Verleden, Geert M, Knoop, Christiane, Boone, Matthieu, Vos, Robin, Verleden, Geert M., Verbeken, Erik   +23 more
core   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source