Results 41 to 50 of about 152,232 (307)

Corneal Allograft Rejection: Immunopathogenesis to Therapeutics [PDF]

, 2014
Corneal transplantation is among the most successful solid organ transplants. However, despite low rejection rates of grafts in the ‘low-risk’ setting, rejection can be as high as 70% when grafted into ‘high-risk’ recipient beds. Under normal homeostatic
Hamrah, Pedram, Qazi, Yureeda
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Heparan sulfate is a plasma biomarker of acute cellular allograft rejection.

PLoS ONE, 2018
Despite advances in management of immunosuppression, graft rejection remains a significant clinical problem in solid organ transplantation. Non-invasive biomarkers of graft rejection can facilitate earlier diagnosis and treatment of acute rejection.
Andrew S Barbas, Liwen Lin, MacKenzie McRae, Andrea L MacDonald, Tracy Truong, Yiping Yang, Todd V Brennan   +6 more
doaj   +1 more source

Lack of Association between Interleukin-10 Gene Polymorphisms and Graft Rejection Risk in Kidney Transplantation Recipients: A Meta-Analysis. [PDF]

PLoS ONE, 2015
Interleukin-10 (IL-10) is an important immunomodulatory cytokine. Several studies focused the association between IL-10 promoter gene polymorphisms and graft rejection risk in kidney transplantation recipients.
Jiachuan Xiong, Yiqin Wang, Ying Zhang, Ling Nie, Daihong Wang, Yunjian Huang, Bing Feng, Jingbo Zhang, Jinghong Zhao   +8 more
doaj   +1 more source

Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]

, 1988
A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Ballardini, Baum, Berg, Bernuau, Demetris, Demetris, Demetris, Demetris, Detre, Epstein, Epstein, Esquivel, Fennell, Fung, Haagsma, Iwatsuki, James, MacSween, McFarlane, McFarlane, Neuberger, Popper, Portmann, Portmann, Portmann, Vento   +25 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection

Transplant International
Chronic graft rejection represents a significant threat to long-term graft survival. Early diagnosis, understanding of the immunological mechanisms and appropriate therapeutic management are essential to improve graft survival and quality of life for ...
Mathilde Chambon, Alice Koenig, Alice Koenig, Alice Koenig   +3 more
doaj   +1 more source

Reduced CD40L expression on ex vivo activated CD4+T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure [PDF]

, 2004
Background: The CD40-CD40L (CD154) costimulatory pathway plays a critical role in the pathogenesis of kidney allograft rejection. In renal transplant biopsies, CD4+ CD40L+ graft-infiltrating cells were detected during chronic rejection in contrast to ...
Friedrich, N., Gruber, R., Landgraf, R., Lederer, Stephan R., Sitter, Thomas, Toepfer, Marcel   +5 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Chronic allograft rejection: A significant hurdle to transplant success

Burns & Trauma, 2014
The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation.
Malgorzata Kloc, Rafik M Ghobrial
doaj   +1 more source