Results 51 to 60 of about 537,363 (298)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing.

PLoS ONE
BackgroundThe demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and reduced graft ...
Xihao Shen, Jiyue Wu, Feilong Zhang, Qing Bi, Zejia Sun, Wei Wang   +5 more
doaj   +1 more source

IL-6 Promotes Cardiac Graft Rejection Mediated by CD4+ Cells

, 2011
IL-6 mediates numerous immunologic effects relevant to transplant rejection; however, its specific contributions to these processes are not fully understood.
Guanyi Lu, Svetlana Grabauskiene, Adam Jared Booth, D. Keith Bishop, Sherri Chan Wood, Bryna E. Burrell   +5 more
core   +1 more source

Factors associated with graft rejection in patients with repeat penetrating keratoplasty (PK).

, 2022
Factors associated with graft rejection in patients with repeat penetrating keratoplasty (PK).
Passara Jongkhajornpong (6490631), Vachira Sontichai (14034779), Sarayut Nijvipakul (1905454), Kaevalin Lekhanont (718791), Varintorn Chuckpaiwong (718794), Pongthep Rajsirisongsri (14034776)   +5 more
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Graft rejection – endogenous or allogeneic?

Immunology, 2012
SummaryThe presence and persistence of alloantigen is necessary for graft‐specific T‐cell‐mediated immunity. However, specificity comprises only a single facet of an extremely complex process. Evidence is accruing to suggest that immunogenicity could be manipulated by endogenous ligands released during tissue injury.
William R, Critchley, James E, Fildes
openaire   +3 more sources

Molecular Phenotypes of Kidney Graft Rejection

, 2011
In the last decade, gene expression studies of kidney transplants provided an opportunity to better understand the development and regulation of kidney graft rejection.
Ondrej Viklicky, Petra Hribova
core   +1 more source

Factors associated with rejection-related graft failure in patients with repeat penetrating keratoplasty (PK).

, 2022
Factors associated with rejection-related graft failure in patients with repeat penetrating keratoplasty (PK).
Passara Jongkhajornpong (6490631), Vachira Sontichai (14034779), Sarayut Nijvipakul (1905454), Kaevalin Lekhanont (718791), Varintorn Chuckpaiwong (718794), Pongthep Rajsirisongsri (14034776)   +5 more
core   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Genetics of Graft Rejection in Douglas-fir

, 1974
Graft rejection in Douglas-fir was controlled primarily by additive genes. Heritability of graft incompatibility was 0.81. No significance for specific combining ability was found.
Donald L. Copes
core   +1 more source