Results 61 to 70 of about 843,026 (292)

42 Is Cortical Mastoidectomy Justified in Tubotympanic Chronic Otitis Media

JK Science, 2022
Objectives: To compare the graft uptake rates and hearing outcomes in cases of tubotympanic chronic otitis media undergoing Tympanoplasty with and without Cortical mastoidectomy.Materials & Methods: It was a prospective study carried out over the period
Anju Chauhan, Samuel Rajan, P.K Rathore, Anoop Raj   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Carboxylates and the uptake of ammonium by excised maize roots [PDF]

, 1975
The effect of carboxylates (organic acid anions) on NH 4 uptake was studied by changing the carboxylate level of roots prior to uptake experi ments. Succinate was the most effective stimulator of ammonium uptake.
Breteler, H.
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Chromium uptake by Fenugreek [PDF]

, 2012
Fenugreek (Trigonella foenum- graecum) is both herb (leaves) and a spice (seed) belonging to the family Fabaceae. Fenugreek leaves and seeds are used in the cuisine of India. Fenugreek also has medicinal value.
Sekhar D M R, Xanthate D S, Murthy Ch V R, Rajan S C S   +3 more
core  

Effects associated with graft-transmissible agents found in the peach variety 'Ta Tao 5' [PDF]

, 2010
The peach variety ‘Ta Tao 5’ is host to at least three graft-transmissible agents. Extraction and characterization of these agents indicates that they are variants of Peach latent mosaic viroid (PLMVd), Apple chlorotic leaf spot virus (ACLSV) and a ...
Gibson, P. G., Reighard, G., Scott, S. W., Marini, D.   +3 more
core   +1 more source

Fibrin glue enhances early hearing recovery in tympanoplasty: A randomised controlled trial

American Journal of Otolaryngology
Objective: To compare the efficacy of fibrin glue versus Gelfoam in cartilage tympanoplasty, focusing on graft uptake rates and short-term hearing outcomes.
Benyamin Rahmaty, Sanam Asgari, Mohammad Sayyadi, Ali Kouhi, Saeed Golparavaran, Ali Aalizade, Mohammad Taghi Khorsandi Ashtiani, Kayvan Aghazadeh   +7 more
doaj   +1 more source