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Biology of Graft-vs.-Host Disease
Journal of Pediatric Hematology/Oncology, 1993Graft-vs.-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation, which is an important approach for the treatment of various diseases. In experimental animal models, lethal GVHD can be induced in major histocompatibility complex (MHC)-matched strain combinations that differ in their expression of multiple minor ...
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Skin Changes in Graft-vs-Host Disease
Southern Medical Journal, 1976In this review of the clinical and histopathologic manifestations of the graft-vs-host reaction, the characteristic changes in the skin are given particular emphasis, since they are among the earliest and most obvious signs of this syndrome. The acute and chronic forms of graft-vs-host disease are distinguished, with notation of their different ...
R L, Spielvogel, S, Ullman, R W, Goltz
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2004
Transplantation immunobiology: thymic T-cell development MHC class 1: structure and function MHC class II: structure and function biological inhibitors of lymphocyte coreceptors for antigen-specific immunosuppression immunosuppression andimmunophilin ligands: cyclosporin A, FK506, and rapamycin leucocyte adhesion, trafficking, and migration cytokine ...
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Transplantation immunobiology: thymic T-cell development MHC class 1: structure and function MHC class II: structure and function biological inhibitors of lymphocyte coreceptors for antigen-specific immunosuppression immunosuppression andimmunophilin ligands: cyclosporin A, FK506, and rapamycin leucocyte adhesion, trafficking, and migration cytokine ...
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Graft–Vs.–Host Disease After Liver Transplantation
Hepatology, 1990Clinically evident, generalized graft–vs.–host disease is not thought to occur as a consequence of transplantation of most solid organs. The large inoculum of donor lymphoid cells required and the inability of the recipient to destroy these passenger cells are apparently rarely produced by solid–organ transplantation. However,
G, Alexander, B, Portmann
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CNS angiitis in graft vs host disease
Neurology, 2002Graft-vs-host disease (GVHD) is a potentially treatable cause of progressive neurologic decline after bone marrow transplantation (BMT). The authors present histologic confirmation of CNS granulomatous angiitis in a child with chronic GVHD after BMT. Since cranial MRI showed only nonspecific findings, CNS vasculitis associated with GVHD after BMT may ...
M, Ma +5 more
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Archives of Dermatology, 1987
• Graft-vs-host disease (GVHD) is a frequent complication of allogeneic bone marrow transplantation but has been infrequently reported following autologous or syngeneic bone marrow transplantation. Ninety-six autologous and 19 syngeneic marrow transplants were performed at our institution between July 1977 and March 1984. We report acute cutaneous GVHD
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• Graft-vs-host disease (GVHD) is a frequent complication of allogeneic bone marrow transplantation but has been infrequently reported following autologous or syngeneic bone marrow transplantation. Ninety-six autologous and 19 syngeneic marrow transplants were performed at our institution between July 1977 and March 1984. We report acute cutaneous GVHD
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Ocular Manifestations of Graft-vs-Host Disease
Ophthalmology, 1983In patients who have graft-vs-host disease (GVHD) after bone marrow transplantation, ocular involvement occurs in approximately 60% of cases. Among 13 such GVHD patients, the most frequent ocular manifestations included keratoconjunctivitis sicca, cicatricial lagophthalmos, and sterile conjunctivitis and uveitis.
R M, Franklin +5 more
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2004
Hemopoietic stem cell transplantation (HSCT) involves the transfer of cells that produce hemopoietic and lymphoid progeny. For donor cells to accept the host environment as “self ” requires that newly developing alloreactive T lymphocytes and mature donor T lymphocytes contained in the transplant inoculum be eliminated or inactivated, and only cells ...
Uwe Platzbecker, H. Joachim Deeg
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Hemopoietic stem cell transplantation (HSCT) involves the transfer of cells that produce hemopoietic and lymphoid progeny. For donor cells to accept the host environment as “self ” requires that newly developing alloreactive T lymphocytes and mature donor T lymphocytes contained in the transplant inoculum be eliminated or inactivated, and only cells ...
Uwe Platzbecker, H. Joachim Deeg
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Antigen presentation in graft-vs-host disease
Experimental Hematology, 2003Graft-vs-host disease (GVHD) and the sequela of immunosuppression used to prevent it remain major causes of morbidity and mortality in allogeneic stem cell transplantation (alloSCT). In particular, GVHD and ineffective T-cell immune reconstitution significantly decreases the enthusiasm for offering alloSCT to patients with non-malignant inherited ...
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Blood Transfusions and Graft-vs-Host Disease
Archives of Dermatology, 1990Decoste et al 1 report on transfusion-associated graft-vs-host disease (GVHD) in this issue of theArchivesand raise important considerations for dermatologists evaluating morbilliform erythemas and exanthems. In healthy individuals, such eruptions are frequently attributed (correctly or otherwise) to a drug sensitivity or reaction, often on criteria of
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