Results 91 to 100 of about 44,177 (299)

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

eLife, 2019
Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear.
Derek J Royer, Jose Echegaray-Mendez, Liwen Lin, Grzegorz B Gmyrek, Rose Mathew, Daniel R Saban, Victor L Perez, Daniel JJ Carr   +7 more
doaj   +1 more source

Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen

, 1999
Mixed hematopoietic chimerism can be induced in mice receiving allogeneic bone marrow transplantation (BMT) after nonmyeloablative host conditioning with depletion T cells with of anti-T cell monoclonal antibodies (mAbs), low-dose (3 Gy) total-body ...
Sykes, Megan, Swenson, Kirsten, Sachs, Jessica, Pelot, Michele R, Pearson, Denise A, Zhao, Guiling, Yang, Yong-Guang   +6 more
core   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, EarlyView.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Looking into nerve damage in the cornea

eLife, 2019
Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye.
Mihaela Gadjeva
doaj   +1 more source

Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease [PDF]

, 2019
Data from both animal models and humans have demonstrated that effector memory T cells (TEM) and central memory T cells (TCM) from unprimed donors have decreased ability to induce graft-vs-host disease (GVHD).
Jieling Jiang, Wei Huang, Wenjian Mo, Nelson J. Chao, Benny J. Chen   +4 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model. [PDF]

, 2019
peer reviewedMesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft- vs.-host disease (GVHD).
BRIQUET, Alexandra, Ehx, Gregory, Ritacco, Caroline, Gregory Ehx (6533978), Céline Grégoire (6533972), Sophie Servais (534177), Servais, Sophie, Yves Beguin (264097), Chantal Lechanteur (6533975), DUBOIS, Sophie, Delens, Loïc, Baron, Frédéric, Ludovic Belle (293091), Sophie Dubois (3476708), Belle, Ludovic, SEIDEL, Laurence, Loïc Delens (758575), Caroline Ritacco (5700995), Frédéric Baron (3394742), Muriel Hannon (380961), LECHANTEUR, Chantal, Beguin, Yves, Veriter, Sophie, Alexandra Briquet (293097), Hannon, Muriel, Sophie Vériter (816353), Grégoire, Céline, Laurence Seidel (380962)   +27 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Table_1_Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study.DOCX

, 2018
Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid ...
Ye Zhao (39959), Faming Zhang (3015579), Xiao Ma (411875), Feng Chen (25347), Depei Wu (239078), Xuewei Li (112102), Xiaojin Wu (4924135), Xiaofei Qi (4670407)   +7 more
core   +1 more source