Results 21 to 30 of about 874,597 (284)

In Vitro Activity of Cefiderocol against Clinical Gram-Negative Isolates Originating from Germany in 2016/17

Antibiotics, 2023
Antimicrobial resistance poses a global threat to public health. Of great concern are Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales with resistance to carbapenems or third-generation cephalosporins. The aim of the present study was
Esther Wohlfarth, Michael Kresken, Fabian Deuchert, Sören G. Gatermann, Yvonne Pfeifer, Niels Pfennigwerth, Harald Seifert, Paul G. Higgins, Guido Werner, Study Group ‘Antimicrobial Resistance‘ of the Paul Ehrlich Society for Infection Therapy   +9 more
doaj   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]

, 2016
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica, Cox, Dermot, Henderson, Ian R., Kerrigan, Steven W., Watson, Callum N., Watson, Steve P.   +5 more
core   +3 more sources

In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia

Frontiers in Cellular and Infection Microbiology, 2023
Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by the United States Centers for Disease Control and Prevention. Here, we used whole genome sequencing (WGS) to investigate recurrent P. aeruginosa bloodstream infections
Natasha Spottiswoode, Samantha Hao, Samantha Hao, Estella Sanchez-Guerrero, Angela M. Detweiler, Honey Mekonen, Norma Neff, Henriette Macmillan, Brian S. Schwartz, Joanne Engel, Joseph L. DeRisi, Joseph L. DeRisi, Steven A. Miller, Steven A. Miller, Charles R. Langelier, Charles R. Langelier   +15 more
doaj   +1 more source

Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil [PDF]

, 2013
Actinomycete strain SA198, isolated from a Saharan soil sample of Algeria, exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, and phytopathogenic and toxinogenic fungi.
A. Lebrihi, A. Zitouni, Andriole, Becker, Berdy, Betina, Buckingham, Bull, Bush, Bycroft, C. Bijani, D. Boubetra, F. Mathieu, Felsenstein, Felsenstein, Genilloud, Hayakawa, Hayakawa, Hosoe, Igarashi, Kalinovskaya, Kelly, Kim, Kimura, Kinochita, Labeda, Lamari, Lass-Flörl, Lazzarini, Lechevalier, Lechevalier, Liu, Locci, Merrouche, Minnikin, Murakami, N. Sabaou, Oki, Sabaou, Sanglier, Shirling, Singh, Stackebrandt, Suzuki, Takahashi, Takeuchi, Tamura, Thompson, Waksman, Wang, Zitouni, Zitouni, Zitouni   +52 more
core   +4 more sources

Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination

Antibiotics, 2020
Antimicrobial resistance (AMR) is one of the most prominent public health threats. AMR genes localized on plasmids can be easily transferred between bacterial isolates by horizontal gene transfer, thereby contributing to the spread of AMR.
Bas Berbers, Pieter-Jan Ceyssens, Pierre Bogaerts, Kevin Vanneste, Nancy H. C. Roosens, Kathleen Marchal, Sigrid C. J. De Keersmaecker   +6 more
doaj   +1 more source

Lipopolysaccharide-specific acyloxyacyl hydrolase [PDF]

, 1991
" An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids from their ester linkages to hydroxy groups of 3-hydroxyfatty acids, the latter being being bound in turn to lipopolysaccharide ...
Hall, Catherine L., Munford, Robert S.
core   +1 more source

Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]

, 2019
O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol, Machado, Henrique, Monk, Jonathan M, Palsson, Bernhard O, Seif, Yara   +4 more
core   +2 more sources

Riemannian Optimization for Skip-Gram Negative Sampling

, 2017
Skip-Gram Negative Sampling (SGNS) word embedding model, well known by its implementation in "word2vec" software, is usually optimized by stochastic gradient descent. However, the optimization of SGNS objective can be viewed as a problem of searching for
Fonarev, Alexander, Gusev, Gleb, Hrinchuk, Oleksii, Oseledets, Ivan, Serdyukov, Pavel   +4 more
core   +1 more source

Gram-negative bacterial molecules associate with Alzheimer disease pathology. [PDF]

, 2016
ObjectiveWe determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative ...
DeCarli, Charles, Jin, Lee-Way, Phinney, Brett, Sharp, Frank R, Stamova, Boryana, Zhan, Xinhua   +5 more
core   +1 more source