Results 11 to 20 of about 612,577 (265)

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Microbial Biotechnology
Natural products have proven themselves as a valuable resource for antibiotics. However, in view of increasing antimicrobial resistance, there is an urgent need for new, structurally diverse agents that have the potential to overcome resistance and treat
Joy Birkelbach, Carsten E. Seyfert, Sebastian Walesch, Rolf Müller   +3 more
doaj   +3 more sources

Gram-Negative Bacterial Lysins [PDF]

Antibiotics, 2020
Antibiotics have had a profound impact on human society by enabling the eradication of otherwise deadly infections. Unfortunately, antibiotic use and overuse has led to the rapid spread of acquired antibiotic resistance, creating a major threat to public
Chandrabali Ghose, Chad W. Euler
doaj   +3 more sources

Gram-Negative Flagella Glycosylation [PDF]

International Journal of Molecular Sciences, 2014
Protein glycosylation had been considered as an eccentricity of a few bacteria. However, through advances in analytical methods and genome sequencing, it is now established that bacteria possess both N-linked and O-linked glycosylation pathways. Both glycosylation pathways can modify multiple proteins, flagellins from Archaea and Eubacteria being one ...
Susana Merino, Juan Tomás
openaire   +3 more sources

Gram-negative bacteraemia in haemodialysis [PDF]

Nephrology Dialysis Transplantation, 2015
Patients on renal replacement therapy experience higher rates of morbidity and mortality, infection being the second commonest cause of death. In our haemodialysis population, we identify the pathogens, sensitivity patterns, sources of infection and outcomes of Gram-negative bacteraemia.Data from the NHS Greater Glasgow & Clyde and NHS Forth Valley ...
Eleanor C, Murray, Aleksandra, Marek, Peter C, Thomson, John E, Coia   +3 more
openaire   +2 more sources

Environmental microbial communications in gram-positive and gram-negative bacteria [PDF]

Global Journal of Environmental Science and Management, 2023
Microorganisms are present in nature and shape an enormous a half of our micro- and macro-environment. Quorum sensing is the process of intercellular conversation that enables microbes to perceive their surroundings and change their behaviour, allowing ...
P. Srikanth, D. Sivakumar, J. Nouri
doaj   +1 more source

Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination

Antibiotics, 2020
Antimicrobial resistance (AMR) is one of the most prominent public health threats. AMR genes localized on plasmids can be easily transferred between bacterial isolates by horizontal gene transfer, thereby contributing to the spread of AMR.
Bas Berbers, Pieter-Jan Ceyssens, Pierre Bogaerts, Kevin Vanneste, Nancy H. C. Roosens, Kathleen Marchal, Sigrid C. J. De Keersmaecker   +6 more
doaj   +1 more source

In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia

Frontiers in Cellular and Infection Microbiology, 2023
Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by the United States Centers for Disease Control and Prevention. Here, we used whole genome sequencing (WGS) to investigate recurrent P. aeruginosa bloodstream infections
Natasha Spottiswoode, Samantha Hao, Samantha Hao, Estella Sanchez-Guerrero, Angela M. Detweiler, Honey Mekonen, Norma Neff, Henriette Macmillan, Brian S. Schwartz, Joanne Engel, Joseph L. DeRisi, Joseph L. DeRisi, Steven A. Miller, Steven A. Miller, Charles R. Langelier, Charles R. Langelier   +15 more
doaj   +1 more source

Molecular surveillance of carbapenemase-producing Pseudomonas aeruginosa at three medical centres in Cologne, Germany

Antimicrobial Resistance and Infection Control, 2019
Background Pseudomonas aeruginosa is a common pathogen causing hospital-acquired infections. Carbapenem resistance in P. aeruginosa is either mediated via a combination of efflux pumps, AmpC overexpression, and porin loss, or through an acquired ...
Elena Schäfer, Monika Malecki, Carlos J. Tellez-Castillo, Niels Pfennigwerth, Lennart Marlinghaus, Paul G. Higgins, Frauke Mattner, Andreas F. Wendel   +7 more
doaj   +1 more source

Comparison of testing methods assessing the in vitro efficacy of the combination of aztreonam with avibactam on multidrug-resistant Gram-negative bacilli

Annals of Clinical Microbiology and Antimicrobials
Background Aztreonam-avibactam (ATM-AVI) combination shows promising effectiveness on most carbapenemase-producing Gram-negatives, yet standardized antibiotic susceptibility testing (AST) methods for evaluating the combination in clinical laboratories is
Corentin Deckers, Florian Bélik, Olivier Denis, Pierre Bogaerts, Isabel Montesinos, Catherine Berhin, Warda Bouchahrouf, Martin Hoebeke, Stephanie Evrard, Nicolas Gilliard, Merve Okur, Te-Din Huang   +11 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source