Results 111 to 120 of about 278,909 (163)
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Unrealized targets in the discovery of antibiotics for Gram-negative bacterial infections
Nature Reviews Drug Discovery, 2023Advances in areas that include genomics, systems biology, protein structure determination and artificial intelligence provide new opportunities for target-based antibacterial drug discovery. The selection of a 'good' new target for direct-acting antibacterial compounds is the first decision, for which multiple criteria must be explored, integrated and ...
Ursula Theuretzbacher +2 more
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Multidrug-resistant Gram-negative bacterial infections
Lancet, TheMultidrug-resistant Gram-negative bacterial infections cause significant morbidity and mortality globally. These pathogens easily acquire antimicrobial resistance (AMR), further highlighting their clinical significance. Third-generation cephalosporin-resistant and carbapenem-resistant Enterobacterales (eg, Escherichia coli and Klebsiella spp ...
Nenad Macesic +2 more
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Treatment of Gram-negative bacterial infections by potentiation of antibiotics
Current Opinion in Microbiology, 2016Infections caused by antibiotic-resistant pathogens, particularly Gram-negative bacteria, represent significant treatment challenges for physicians resulting in high rates of morbidity and mortality. The outer membrane of Gram-negative bacteria acts as a permeability barrier to many compounds that would otherwise be effective antibacterial agents ...
Thomas P, Zabawa +3 more
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Gram-negative bacterial infections of the mammary gland in cows
American Journal of Veterinary Research, 1991SUMMARY Naturally acquired gram-negative bacterial intramammary infections (n= 160) were studied in 99 cows over a 2-year period. Escherichia coli, Klebsiella spp, Serratia spp, Enterobacter spp, and unidentified gram-negative bacteria were isolated from 28.8, 39.4, 9.4, 5.0, and 11.2%, respectively, of infected mammary glands.
D A, Todhunter +3 more
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Combating multidrug-resistant Gram-negative bacterial infections
Expert Opinion on Investigational Drugs, 2013Multidrug-resistant (MDR) bacterial infections, especially those caused by Gram-negative pathogens, have emerged as one of the world's greatest health threats. The development of novel antibiotics to treat MDR Gram-negative bacteria has, however, stagnated over the last half century.This review provides an overview of recent R&D activities in the ...
Ze-Qi, Xu +2 more
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An update on endotoxin neutralization strategies in Gram-negative bacterial infections
Expert Review of Anti-infective Therapy, 2020Gram-negative bacterial infections represent still a severe problem of human health care, regarding the increase in multi-resistance against classical antibiotics and the lack of newly developed antimicrobials. For the fight against these germs, anti-infective agents must overcome and/or bind to the Gram-negative outer membrane consisting of a ...
Klaus Brandenburg +7 more
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