Carbapenem-Resistant Gram-Negative Bacterial Infections in Children
Carbapenem-resistant organisms (CRO) are a major global public health threat. Enterobacterales hydrolyze almost all β-lactams through carbapenemase production. Infections caused by CRO are challenging to treat due to the limited number of antimicrobial options. This leads to significant morbidity and mortality. Over
Aguilera-Alonso, David +4 more
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Epidemiology of antibiotic resistance in culture-positive hospitalized patients in selected hospitals in Khartoum, Sudan [PDF]
Objective: To study the prevelence of antibiotic resistance and the prevalent bacterial isolates in hospitalized patients in Khartoum hospitals. Materials & Methods: A cross-sectional prevalence study was carried out during the period of April ...
Abdalrahman, Ihab B +3 more
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Gram-negative bacteria include a number of pathogens that cause disease in humans and animals. Although antibiotics are still effective in treating a considerable range of infections caused by Gram-negative bacteria, the alarming increase of ...
Zhuang Zhu +3 more
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Bacterial infections in patients with liver cirrhosis and ascites [PDF]
Introduction. Bacterial infections are common complications and the cause of death in patients with cirrhosis and ascites. There is no standard method for a rapid and low-cost diagnosis, and its prognosis is poor. Objective.
Marković-Živković Bojana +6 more
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Antibacterial and anti-quorum sensing activities of selected italian honeys against antibiotic-resistant pathogens [PDF]
Three nectar honeys (eucalyptus, thyme and forest) and two honeydew honeys (fir and Metcalfa) from Italy were tested for their antibacterial activity against pathogens commonly associated with wound and burn infections, including methicillin-resistant ...
Fidaleo, Marco +2 more
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Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection [PDF]
Increased susceptibility to co-infection with enteric Gram-negative bacteria, particularly non-typhoidal Salmonella, is reported in malaria and Oroya fever (Bartonella bacilliformis infection), and can lead to increased mortality. Accumulating epidemiological evidence indicates a causal association with risk of bacterial co-infection, rather than just ...
Cunnington, A, Orf, K
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Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
A +173 more
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Background Infections caused by multi-drug resistant gram-negative bacterial infections are the principle threats to the critically ill patients of intensive care units.
Shraddha Siwakoti +5 more
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Measures to eradicate multidrug-resistant organism outbreaks: How much does it cost? [PDF]
This study aimed to assess the economic burden of infection control measures that succeeded in eradicating multidrug-resistant organisms (MDROs) in emerging epidemic contexts in hospital settings.
Birgand, GJC +6 more
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Imipenem/Cilastatin/Relebactam: A Review in Gram-Negative Bacterial Infections [PDF]
Imipenem/cilastatin/relebactam (Recarbrio™) is an intravenously administered combination of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel β-lactamase inhibitor relebactam. Relebactam is a potent inhibitor of class A and class C β-lactamases, conferring imipenem activity against many imipenem-nonsusceptible ...
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