Results 51 to 60 of about 6,569,074 (300)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Activity of Specialized Biomolecules against Gram-Positive and Gram-Negative Bacteria
Antibiotics, 2020 The increased resistance of bacteria against conventional pharmaceutical solutions, the antibiotics, has raised serious health concerns. This has stimulated interest in the development of bio-based therapeutics with limited resistance, namely, essential ...
Tânia D. Tavares +7 more
doaj +1 more source
New quinolones and gram-positive bacteria [PDF]
Antimicrobial Agents and Chemotherapy, 1994 The quinolone class of antibacterial agents has evolved rapidly to emerge as one of the most effective classes of drugs in the treatment of infectious diseases. While the spectra and antibacterial activities of fluoroquinolones, such as ciprofloxacin, developed in the 1980s improved to include most gramnegative bacteria, their activities against gram ...
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Gram Positive Bacteria in Clinical Medicine
, 2020 Presented at the ELWA Family Medicine Residency Program, Liberia, on July 7 2020.The goals of this presentation are to: define the molecular structure of Gram-positive organisms; highlight differences between Gram-positives and Gram-negatives; discuss ...
Hatch, Steven C.
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Journal of the Dow University of Health Sciences, 2010 Objective: Blood stream infections (BSI) (septicemias) require prompt empirical therapy based on awarenessof the drug susceptibility profiles of locally prevalent pathogens isolated.
Farhan Essa Abdullah +2 more
doaj +4 more sources
Antibiogram results for the Gram-positive cultured bacteria.
, 2022 Antibiogram results for the Gram-positive cultured bacteria.
Michael Häfner (3335652) +6 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source