Results 41 to 50 of about 54,367 (305)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

A meta-analysis of sensitivity to grammatical information during self-paced reading: Towards a framework of reference for reading time effect sizes. [PDF]

open access: yes, 2019
Despite extensive theoretical and empirical research, we do not have estimations of the magnitude of sensitivity to grammatical information during L2 online processing.
Avery, Nicholas, Marsden, Emma Josephine
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Grammatical Gender in Interaction: cultural and cognitive aspects [PDF]

open access: yes, 2014
In Grammatical Gender in Interaction: Cultural and Cognitive Aspects Angeliki Alvanoudi explores the relation between grammatical gender in person reference, culture and cognition in Modern Greek conversation.
Alvanoudi, Angeliki
core  

An Analytical Study of the Grammatical Cohesive Devices Used in the Farewell Sermon of the Prophet Muhammed

open access: yesمجلة ابحاث كلية التربية الاساسية
This study analyzes the grammatical cohesive devices in the Farewell Sermon of Prophet Muhammad (peace be upon him) using Halliday and Hasan's (1976) model.
Raghad Hamid
doaj   +1 more source

Use of Grammatical Cohesion in Argumentative Essays

open access: yesAnkara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi, 2018
Grammatical cohesion is the basic means of establishing connection between texts, words, word groups, phrases and sentences as well as ideas. Linguistically, grammatical cohesion can be possible through reference, conjunctions, substitution and ellipsis.
Bilge ÖZTÜRK
doaj   +1 more source

On grammatical relations as constraints on referent identification [PDF]

open access: yes, 2006
Based on a Relevance Theory-informed view of language development, this paper argues that grammatical relations are construction-specific conventionalizations (grammaticalizations) of implicatures which arise out of repeated patterns of reference to particular types of referents.
openaire   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

The Analysis of Grammatical and Textual Equivalence Used in The Translation of Paolini‘s Novel of “Inheritance” into Indonesian

open access: yesRegister Journal, 2016
This study examines kinds of grammatical and textual equivalence which are used by Poppy D. Chusfani in translating English into Indonesia language of Christopher Paolini‘s Novel of “Inheritance” as well as the most dominant equivalence used by Poppy D ...
Badi’atul Azmina
doaj   +1 more source

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