Results 51 to 60 of about 4,689,119 (260)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Extending Global Value Chain Governance: Addressing Grand Challenges in Amazonian Rainforest
RAC: Revista de Administração ContemporâneaObjective: the rise of grand challenges such as climate change and deforestation raises questions about how Global Value Chains (GVC) respond to such pressures.
Lucas Gabriel Bezerra Lima +1 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
, 2020 A blog post originally appearing on the Paris Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W. Mellon Foundation Grand Challenges Initiative of Hope College (Nations, Citizens, and Outsiders: Paris
Grand Challenges at Hope College, Mellon Foundation
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Thrombosis: Grand Challenges Ahead!
Frontiers in Cardiovascular Medicine, 2021 Hugo ten Cate, Hugo ten Cate
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
, 2018 A blog post originally appearing on the Archive Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W.
Grand Challenges at Hope College, Mellon Foundation
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Teaching & Learning Inquiry: The ISSOTL JournalResearch on the learning- and engagement-related impacts of choice in assessment is growing, though it often focuses on a single kind of choice with insufficient attention to the learning priorities and motivations behind students’ decisions.
Sarah Copland +2 more
doaj +1 more source