Results 71 to 80 of about 4,689,119 (260)

Student Work

, 2019
A blog post originally appearing on the Archive Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W.
Grand Challenges at Hope College, Mellon Foundation
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Paris May Term, 2019: Looking Forward, Looking Back

, 2018
A blog post originally appearing on the Paris Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W. Mellon Foundation Grand Challenges Initiative of Hope College (Nations, Citizens, and Outsiders: Paris
Grand Challenges at Hope College, Mellon Foundation
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

THE ARCTIC: GRAND CHALLENGES

Север и рынок: формирование экономического порядка
This article examines the historical development of the Russian Arctic, the current status of Russia’s claims to extend its continental shelf, and the delimitation of maritime boundaries under the United Nations Convention on the Law of the Sea.
Ivan G. Tananaev, Sergey V. Krivovichev, Sergey M. Aksenov   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Grand Challenges

Frontiers in Immunology, 2011
Bernhard eMoser
doaj   +1 more source

Grand Challenges in Astrostatistics

Frontiers in Astronomy and Space Sciences, 2020
Didier Fraix-Burnet
doaj   +1 more source

Developmental Physiology: Grand Challenges

Frontiers in Physiology, 2021
Warren Burggren
doaj   +1 more source