Results 61 to 70 of about 4,689,119 (260)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Prácticas estratégicas y grandes desafíos: Una revisión de literatura desde la estrategia como práctica en contexto latinoamericano

Innovar: Revista de Ciencias Administrativas y Sociales
Los Grand Challenges representan problemas complejos cuya respuesta depende, en gran medida, de las prácticas desarrolladas por las organizaciones. Sin embargo, aún se conoce poco sobre cómo dichas prácticas son reconocidas como estratégicas desde la ...
Lucia Palacios Moya, Rosalía Aldraci Barbosa Lavarda, Eduardo Guedes Villar, Martha E. Reyes Sarmiento   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Grand Challenges in Agentic AI for Cyber Operations: A Research Agenda

The Cyber Defense Review
Agentic AI systems are reshaping cyber operations at a pace that outstrips the mechanisms needed to deploy them responsibly. The first documented autonomous cyber attack, in September 2025, demonstrated that the technology has crossed the threshold from ...
Kyle Dotterrer, Allyson Hauptman, Blane Richoux, Matthew Corbett   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Paris Stories (All Posts)

, 2019
All blog posts appearing on the Paris Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W. Mellon Foundation Grand Challenges Initiative of Hope College (Nations, Citizens, and Outsiders: Paris Stories)
Grand Challenges at Hope College, Mellon Foundation
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Nadia Boulanger Collection (May 2018)

, 2018
A blog post originally appearing on the Archive Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W.
Grand Challenges at Hope College, Mellon Foundation
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Grand Challenges in Coevolution

Frontiers in Ecology and Evolution, 2022
Mónica Medina, David M. Baker, David A. Baltrus, Gordon M. Bennett, Ulisse Cardini, Adrienne M. S. Correa, Sandie M. Degnan, Gregor Christa, Eunsoo Kim, Jingchun Li, David R. Nash, Ezequiel Marzinelli, Michele Nishiguchi, Carlos Prada, Melissa S. Roth, Mahasweta Saha, Christopher I. Smith, Kevin R. Theis, Jesse Zaneveld   +18 more
doaj   +1 more source