Results 81 to 90 of about 119,582 (346)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Implications of a dark grand unification

Journal of High Energy Physics
Given that dark matter and normal matter are nontrivially unified in a grand unified theory, called dark grand unification, we derive novel residual theories at low energy explaining dark matter and neutrino mass.
Phung Van Dong, Do Thi Huong
doaj   +1 more source

Frozen up dilaton and the GUT/Planck mass ratio

Physics Letters B, 2017
By treating modulus and phase on equal footing, as prescribed by Dirac, local scale invariance can consistently accompany any Brans–Dicke ω-theory. We show that in the presence of a soft scale symmetry breaking term, the classical solution, if it exists,
Aharon Davidson, Tomer Ygael
doaj   +1 more source

Proton decay and axion dark matter in SO(10) grand unification via minimal left–right symmetry

European Physical Journal C: Particles and Fields, 2020
We study the proton lifetime in the SO(10) Grand Unified Theory (GUT), which has the left–right (LR) symmetric gauge theory below the GUT scale. In particular, we focus on the minimal model without the bi-doublet Higgs field in the LR symmetric model ...
Yuta Hamada, Masahiro Ibe, Yu Muramatsu, Kin-ya Oda, Norimi Yokozaki   +4 more
doaj   +1 more source

Can leptonic mixing matrix have a Wolfenstein form?

Journal of High Energy Physics, 2023
We analyze the possibility of the leptonic mixing matrix having a Wolfenstein form at the Grand Unified Theory scale. The renormalization group evolution of masses and mixing angles from the high scale to electroweak scale, in certain new physics ...
Ankur Panchal, G. Rajasekaran, Rahul Srivastava   +2 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

SU(5)×U(1)X grand unification with minimal seesaw and Z′-portal dark matter

Physics Letters B, 2018
We propose a grand unified SU(5)×U(1)X model, where the standard SU(5) grand unified theory is supplemented by minimal seesaw and a right-handed neutrino dark matter with an introduction of a global Z2-parity.
Nobuchika Okada, Satomi Okada, Digesh Raut   +2 more
doaj   +1 more source

Grand Unified Theories

, 2006
22 pages, 18 figures, Invited talk given at the 2nd World Summit on Physics Beyond the Standard Model, Galapagos Islands, Ecuador, June 22-25 ...
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

GUT origins of general electroweak multiplets and their oblique parameters

Nuclear Physics B
We survey the scalar electroweak multiplets that can originate from a grand unified theory (GUT) like SU(5), SO(10) or E6. We compute the oblique parameters S, T and U for a general scalar electroweak multiplet and then apply the results to the ...
Liang Chen, Ta-Wei Chan, Thomas W. Kephart, Wai Yee Keung, Tzu-Chiang Yuan   +4 more
doaj   +1 more source