Results 71 to 80 of about 4,875 (298)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Locally supersymmetric SU(6) grand unified theory without fine-tuning and strong CP problems
, 1985 We construct a realistic supersymmetric SU(6) grand unified theory with a natural solution of the fine-tuning and the strong CP problems.
Sen, Ashoke
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Implications of a dark grand unification
Journal of High Energy PhysicsGiven that dark matter and normal matter are nontrivially unified in a grand unified theory, called dark grand unification, we derive novel residual theories at low energy explaining dark matter and neutrino mass.
Phung Van Dong, Do Thi Huong
doaj +1 more source
Flavon alignments from orbifolding: SU(5) × SU(3) model with 𝕋6 /∆(54)
Journal of High Energy Physics, 2019 We systematically develop the formalism necessary for ensuring that boundary conditions of flavon fields in extra dimensions are consistent with heterotic string theory.
Francisco J. de Anda +3 more
doaj +1 more source
The Partial Eclipse of Plotinus in the Middle Ages and his Recovery in the Renaissance
Patristica et Mediaevalia, 2019 This article studies the Plotinian presence in the Middle Ages and the Renaissance. First, it accounts for the indirect transmission of the Enneads throughout Medieval times and the editions that reappears in the Renaissance. In this regard, it discusses
Kevin Corrigan
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Frozen up dilaton and the GUT/Planck mass ratio
Physics Letters B, 2017 By treating modulus and phase on equal footing, as prescribed by Dirac, local scale invariance can consistently accompany any Brans–Dicke ω-theory. We show that in the presence of a soft scale symmetry breaking term, the classical solution, if it exists,
Aharon Davidson, Tomer Ygael
doaj +1 more source
, 1982 For pt.I see report no. CERN TH-3174 (1981). The inadequacies of the standard SU(3)*SU(2)*U(1) model of the strong, weak, and electromagnetic interactions motivate the construction of grand unified theories (GUTs). The strategy then adopted was to assign
Ellis, Jonathan Richard
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source