Results 81 to 90 of about 4,875 (298)

SU(5)×U(1)X grand unification with minimal seesaw and Z′-portal dark matter

open access: yesPhysics Letters B, 2018
We propose a grand unified SU(5)×U(1)X model, where the standard SU(5) grand unified theory is supplemented by minimal seesaw and a right-handed neutrino dark matter with an introduction of a global Z2-parity.
Nobuchika Okada   +2 more
doaj   +1 more source

Proton decay and axion dark matter in SO(10) grand unification via minimal left–right symmetry

open access: yesEuropean Physical Journal C: Particles and Fields, 2020
We study the proton lifetime in the SO(10) Grand Unified Theory (GUT), which has the left–right (LR) symmetric gauge theory below the GUT scale. In particular, we focus on the minimal model without the bi-doublet Higgs field in the LR symmetric model ...
Yuta Hamada   +4 more
doaj   +1 more source

Light Threshold Effects in Supersymmetric Grand Unified Theories [PDF]

open access: yes, 1993
Supersymmetric Grand Unified Theories have a rich spectrum of particles barely heavier than the intermediate vector bosons. As their non-supersymmetric counterparts, they lead to many relations among low energy observables.
Grinstein, B., Faraggi, A. E.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

GUT origins of general electroweak multiplets and their oblique parameters

open access: yesNuclear Physics B
We survey the scalar electroweak multiplets that can originate from a grand unified theory (GUT) like SU(5), SO(10) or E6. We compute the oblique parameters S, T and U for a general scalar electroweak multiplet and then apply the results to the ...
Liang Chen   +4 more
doaj   +1 more source

Chirality in unified theories of gravity

open access: yes, 2010
We show how to obtain a single chiral family of an SOð10Þ grand unified theory (GUT), starting from a Majorana-Weyl representation of a unifying (GraviGUT) group SOð3; 11Þ, which contains the gravita- tional Lorentz group SOð3; 1Þ. An action is proposed,
Percacci R.   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Grand unified theory

open access: yes, 1989
The basic philosophy of a fundamental physicist is that the universe is a beautiful and simplistic thing that can be explained by a generalization. Grand unified theory is the formalism that attempts to unify different theories of different phenomena ...
Don Williams II
core  

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