Results 111 to 120 of about 5,501,717 (307)

Granule Cell Raphes and Parasagittal Domains of Purkinje Cells: Complementary Patterns in the Developing Chick Cerebellum

, 1998
The extensive migration of granule cells and the parasagittal organization of Purkinje cells are two prominent features of cerebellar development. Using granule cell markers, we observed that the inward migration of a subset of granule cells occurs in ...
John C. Lin, Constance L. Cepko
core   +1 more source

Differential expression of cell surface- and dense granule-associated Neospora caninum proteins in tachyzoites and bradyzoites.

, 1998
Morphologically, the tachyzoites and the tissue cysts of Neospora caninum are difficult to distinguish from those of other cyst-forming apicomplexan parasites such as Toxoplasma gondii. Several stage-specific antigens have been identified in T.
Fuchs, N, Gottstein, Bruno, Hemphill, A, Sonda, S   +3 more
core  

Investigating the interplay between excitatory neurotransmission and GABAa receptor expression and trafficking in the stargazer mutant mouse [PDF]

, 2006
The stargazer mutant mouse is an animal model of human absence epilepsy and cerebellar ataxia. The stargazer mutation results in the complete ablation of expression of TARPy2， an AMPA receptor (AMPAR) auxiliary subunit.
Payne, Helen Louise
core  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons

Frontiers in Cellular Neuroscience, 2018
The dentate gyrus (DG) receives highly processed information from the associative cortices functionally integrated in the trisynaptic hippocampal circuit, which contributes to the formation of new episodic memories and the spontaneous exploration of ...
Maryam Hatami, Sabine Conrad, Pooyan Naghsh, Gonzalo Alvarez-Bolado, Thomas Skutella   +4 more
doaj   +1 more source

SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors [PDF]

, 2019
Growth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate ...
Petroni M., Coppa A., Di Giulio S., Nicolis Di Robilant V., Cardinali B., Belardinilli F., Tessitore A., Capalbo C., Pedretti F., Infante P., De Smaele E., Moretti M., Giubettini M., Alfano V., Ramponi V., Fabretti F., Sardina F., Giannini G., De Panfilis S., Sahun Roncero M., Corsi A., Canettieri G., Colicchia V., Fabretti, F, De Panfilis Simone, Alfano, V, Giubettini Maria, Coppa Anna, Roncero Maria Sahun, Infante Paola, Di, Robilant VN, Colicchia Valeria, Belardinilli Francesca, Cardinali Beatrice, De, Panfilis S, Giubettini, M, Sardina Francesca, Alfano Vincenzo, Roncero, MS, Pedretti Flaminia, De Smaele Enrico, Fabretti Francesca, Giannini Giuseppe, Capalbo Carlo, Ramponi, V, Corsi, A, Moretti Marta, Moretti, M, Petroni, M, Corsi Alessandro, Di Giulio Stefano, Tessitore Alessandra, Petroni Marialaura, Di Robilant Vittoria Nicolis, Ramponi Valentina, Canettieri Gianluca   +55 more
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Genome-wide analysis of gene expression and alternative splicing in human medulloblastoma [PDF]

, 2010
Medulloblastoma is a malignant embryonal tumour of the cerebellum which most commonly affects children. A subset of tumours is thought to arise from cerebellar granule cell precursors (GCPs) that fail to undergo normal neuronal development, following ...
Menghi, F.
core  

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

The transmembrane semaphorin Sema6A controls cerebellar granule cell migration

, 2005
The transmembrane semaphorin protein Sema6A is broadly expressed in the developing nervous system. Sema6A repels several classes of developing axons in vitro and contributes to thalamocortical axon guidance in vivo.
Alain Chédotal, Cécile Haumaitre, Kevin J Mitchell, Schneider-Maunoury, Sylvie, Chedotal, A., Jackie Dolan, Haumaitre, Cécile, Fujisawa, H., Géraldine Kerjan, Mitchell, K.J., Hajime Fujisawa, Sylvie Schneider-Maunoury, Kerjan, G., Dolan, J.   +13 more
core   +1 more source