Results 1 to 10 of about 178,478 (306)

Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

iScience
Summary: In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca2+-binding/trafficking protein, Cab45G, serves as a non-
Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede   +21 more
doaj   +1 more source

Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells

Nature Communications, 2019
Fast-spiking parvalbumin-expressing interneurons (PVIs) and granule cells of the dentate gyrus receive layer-specific dendritic inhibition. The authors show that distal and proximal dendritic inhibition differentially control input-output transformations
Claudio Elgueta, Marlene Bartos
doaj   +1 more source

Specific Temporal Distribution and Subcellular Localization of a Functional Vesicular Nucleotide Transporter (VNUT) in Cerebellar Granule Neurons

Frontiers in Pharmacology, 2017
Adenosine triphosphate (ATP) is an important extracellular neurotransmitter that participates in several critical processes like cell differentiation, neuroprotection or axon guidance.
Aida Menéndez-Méndez, Aida Menéndez-Méndez, Aida Menéndez-Méndez, Juan I. Díaz-Hernández, Juan I. Díaz-Hernández, Juan I. Díaz-Hernández, Felipe Ortega, Felipe Ortega, Felipe Ortega, Javier Gualix, Javier Gualix, Javier Gualix, Rosa Gómez-Villafuertes, Rosa Gómez-Villafuertes, Rosa Gómez-Villafuertes, María T. Miras-Portugal, María T. Miras-Portugal, María T. Miras-Portugal   +17 more
doaj   +1 more source

Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb

Frontiers in Integrative Neuroscience, 2010
Odors are encoded in spatio-temporal patterns within the olfactory bulb, but the mechanisms of odor recognition and discrimination are poorly understood.
Michele Migliore, Michele Migliore, Michael Hines, Thomas S McTavish, Gordon M Shepherd   +4 more
doaj   +1 more source

Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway

Cell Death Discovery
Mast cells contribute to the pathology of various diseases, in particular allergic conditions. Therefore, it is essential to develop strategies that efficiently prevent their harmful effects under such circumstances.
Marianthi Vraila, Jun Mei Hu Frisk, Animamalar Mayavannan, Mirjana Grujic, Erik Stigare, Adnan Lidian, Jenny Hallgren, Gunnar Pejler   +7 more
doaj   +1 more source

Lifelong restructuring of 3D genome architecture in cerebellar granule cells. [PDF]

Science, 2023
Tan L, Shi J, Moghadami S, Parasar B, Wright CP, Seo Y, Vallejo K, Cobos I, Duncan L, Chen R, Deisseroth K.   +10 more
europepmc   +1 more source

Complex excitability and "flipping" of granule cells: An experimental and computational study. [PDF]

PLoS One
Danielewicz J, Girier G, Chizhov A, Desroches M, Encinas JM, Rodrigues S.   +5 more
europepmc   +1 more source

Overexpression of Synaptopodin increases the number of spine apparatuses and active synapses of dentate granule cells. [PDF]

Sci Rep
Del Turco D, Paul MH, Rietsche M, Schlaudraff J, Kreuzer A, Mittag M, Drakew A, Jedlicka P, Bas-Orth C, Roeper J, Deller T.   +10 more
europepmc   +1 more source

Gene deletion of Klotho in the dentate gyrus does not affect the number of adult-born granule cells. [PDF]

Sci Rep
Kraus P, Marunde M, Ryzynski A, Düzel E, Kaether C, Kreutz MR, Oelschlegel AM.   +6 more
europepmc   +1 more source

Numbers of Granule Cells and GABAergic Boutons Are Correlated in Shrunken Sclerotic Hippocampi of Sea Lions with Temporal Lobe Epilepsy. [PDF]

eNeuro
Wyeth M, Krucik DDR, Thorbrogger CJ, Field C, Buckmaster PS.   +4 more
europepmc   +1 more source