Global remapping in granule cells and mossy cells of the mouse dentate gyrus [PDF]
Cell Reports, 2023 Summary: Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables.
Sang Hoon Kim +7 more
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways [PDF]
Frontiers in Cellular Neuroscience, 2020 Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Joan Y. W. Liu +9 more
doaj +3 more sources
Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum
Frontiers in Neural Circuits, 2021 Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the brain: at least 99% of all cerebellar neurons are granule cells.
G. Giacomo Consalez +3 more
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Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells
Neurobiology of Disease, 2016 Abnormal hippocampal granule cells are present in patients with temporal lobe epilepsy, and are a prominent feature of most animal models of the disease. These abnormal cells are hypothesized to contribute to epileptogenesis.
Candi L. LaSarge +3 more
doaj +3 more sources
Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus [PDF]
Epilepsy Research, 2003 Granule cells with hilar basal dendrites (HBDs) are found after status epilepticus (SE) in three rat models of temporal lobe epilepsy. These granule cells are commonly located at the hilar border and could be newly born granule cells based on their ...
Khashayar Dashtipour, Igor Spigelman
exaly +2 more sources
BMC Biology, 2021 Background Cerebellar neurogenesis involves the generation of large numbers of cerebellar granule neurons (GNs) throughout development of the cerebellum, a process that involves tight regulation of proliferation and differentiation of granule neuron ...
Wenqin Luo +13 more
doaj +1 more source
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition. [PDF]
, 2013 GABAA receptors (GABARs) are the targets of a wide variety of modulatory drugs which enhance chloride flux through GABAR ion channels. Certain GABAR modulators appear to acutely enhance the function of δ subunit-containing GABAR subtypes responsible for ...
Karakossian, Movses H +3 more
core +10 more sources
Differential Structural Development of Adult-Born Septal Hippocampal Granule Cells in the Thy1-GFP Mouse, Nuclear Size as a New Index of Maturation. [PDF]
PLoS ONE, 2015 Adult neurogenesis is frequently studied in the mouse hippocampus. We examined the morphological development of adult-born, immature granule cells in the suprapyramidal blade of the septal dentate gyrus over the period of 7-77 days after mitosis with ...
Tijana Radic +4 more
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Frontiers in Cellular Neuroscience, 2021 Olfactory bulb and higher processing areas are synaptically interconnected, providing rapid regulation of olfactory bulb circuit dynamics and sensory processing. Short-term plasticity changes at any of these synapses could modulate sensory processing and
Fu-Wen Zhou, Adam C. Puche
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background On encountering a susceptible target, natural killer (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation.
Torsten Tonn +6 more
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