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Cell Culture of Primary Cerebellar Granule Cells

2010
Cerebellar granule cells are often used as a model system for the study of neuronal development, function and pathology, including the analysis of activity-dependent survival/apoptosis of neurons and the mechanisms of neuroprotection. Cerebellar granule cells are generated postnatally and constitute the largest homogeneous neuronal population of the ...
Dana, Krämer, Liliana, Minichiello
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Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the Cerebellar Granule Cell Layer

Journal of Neurophysiology, 1998
Maex, Reinoud and Erik De Schutter. Synchronization of Golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. J. Neurophysiol. 80: 2521–2537, 1998. The granular layer of the cerebellum has a disproportionately large number of excitatory (granule cells) versus inhibitory neurons (Golgi cells).
Maex, Reinoud, De Schutter, Erik
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Cerebellar granule cells expand their talents

Nature Neuroscience, 2017
Technical advances in calcium imaging enable the first tests of classic theories of cerebellar learning. Two independent groups reveal dense representation of surprising modalities in cerebellar granule cells.
Matthew I, Becker, Abigail L, Person
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Ultrastructure of human mast-cell granules

Journal of Ultrastructure Research, 1968
The ultrastructure of the mast-cell granule was studied in skin specimens of urticaria pigmentosa. The granules showed mainly two structural components, i.e., lamellae of a maximal width of 125 A and a fine granular material. The mature granules showed parallel-arranged lamellae, each of which had a periodicity of 60 A. The lamellae formed multilayered
T, Kobayasi   +2 more
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Lysosomal enzymes in the juxtaglomerular cell granules

Experientia, 1979
In addition to the already known acid phosphatase and beta-glucuronidase, 2 other lysosomal enzymes: aryl sulphatase and N-acetyl-beta-glucosaminidase were localized by histochemical methods in the renin-containing granules of the mouse juxtaglomerular cells.
B M, Soltész, S, Gomba, M, Szokol
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Effect of Age on Mast Cell Granules

International Archives of Allergy and Applied Immunology, 2009
Padawer has proposed that rat mast cells in the peritoneal cavity have an extended lifespan and under normal conditions exhibit little turnover of their secretory granules. We have examined several constituents of the granules as part of a study of the structure and function of these organelles. The previously described increase in volume of mast cells
P G, Krüger, D, Lagunoff
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The occurrence of intramitochondrial granules in nerve cells

Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, 1968
The mitochondria of spinal cord motoneurons of normal rats have been studied and compared with those of animals given 2.5 mg/kg of strychnine sulfate. The mitochondria in the motoneurons of the treated animals exhibited opaque granules in the matrix.
R D, Yates, J C, Yates
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Specification of Granule Cells and Purkinje Cells

2019
Granule cells and Purkinje cells are the major populations of neurons in the cerebellum. Their specification depends on a combination of regional identity and spatiotemporal cues. These are conferred by patterning systems in the early embryo that determine anteroposterior and dorsoventral positional coordinates and an age-dependent signal (or signals ...
Thomas Butts   +4 more
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Granulated Round Cell Tumor of Cats

Veterinary Pathology, 1993
Morphologic and biologic features of five feline granulated round cell tumors were compared with those previously reported to be of globule leukocyte and large granular lymphocyte origin. The five cats ranged from 6 to 9 years of age and presented with nonspecific gastrointestinal signs.
M F, McEntee   +3 more
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Cerebellar Granule cells

1996
Abstract From a casual scan of the literature, it appears that rodent cerebellar granule cell cultures are being used in increasing numbers to address different questions in neurobiology. There are good reasons for this: the cultures are relatively easy to prepare, the starting material is neonatal rat pup thus avoiding the use of ...
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