Results 111 to 120 of about 73,182 (298)

Antitumor Activity of Tumor‐Infiltrating Neutrophils Revealed by a Syngeneic Mouse Model of Cholangiocarcinoma

open access: yesCancer Science, EarlyView.
This study developed a genetically engineered and transplantable cholangiocarcinoma (CCA) organoid model in immunocompetent mice to investigate the role of tumor‐infiltrating immune cells in CCA progression. The findings revealed that tumor‐infiltrating neutrophils (TINs) exhibit antitumor activity by directly killing cancer cells through reactive ...
Osamu Sugahara   +6 more
wiley   +1 more source

Treatment of Crohn’s disease with colony-stimulating factors: An overview

open access: yesTherapeutics and Clinical Risk Management, 2008
Luisa Guidi1, Giammarco Mocci1, Manuela Marzo1, Sergio Rutella21Department of Internal Medicine, Operative Unit of Gastroenterology, and 2Department of Hematology, Laboratory of Immunology, Università Cattolica del Sacro Cuore, Rome ...
Luisa Guidi   +3 more
doaj  

Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis

open access: yesContact Dermatitis, EarlyView.
ABSTRACT Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should ...
Meital Portugal‐Cohen   +9 more
wiley   +1 more source

The Carba Mix—In Vitro Investigations of Potential Cocktail Effects in Patch Tests With Rubber Allergens

open access: yesContact Dermatitis, EarlyView.
The carba mix was studied in a human cell model to better understand human patch reactions to the mix. Our results support that the carba mix can give rise to cocktail effect and that patch testing with separate carba mix sensitisers may thus be more appropriate.
Linda Ljungberg Silic   +5 more
wiley   +1 more source

Granulocyte-Macrophage Colony-Stimulating Factor Influence on Soluble and Membrane-Bound ICOS in Combination with Immune Checkpoint Blockade. [PDF]

open access: yesCancer Immunol Res, 2023
Li X   +8 more
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

open access: yesCell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan   +5 more
wiley   +1 more source

Biologic properties in vitro of a recombinant human granulocyte- macrophage colony-stimulating factor [PDF]

open access: bronze, 1986
D Metcalf   +9 more
openalex   +1 more source

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