Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration
Cell Proliferation, EarlyView.Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen +9 more
wiley +1 more source
New treatment options in the management of IBD – focus on colony stimulating factors
Biologics: Targets & Therapy, 2008 Josué Barahona-Garrido, Jesús K Yamamoto-FurushoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán& ...
Josué Barahona-Garrido +1 more
doaj
Response to inhaled granulocyte-macrophage colony-stimulating factor in patient with mild-to-moderate autoimmune pulmonary alveolar proteinosis-24 months of follow-up. [PDF]
Clin Respir J, 2023 Oterino-Moreira I +3 more
europepmc +1 more source
Neutrophils in the Bone Marrow Express DEC205, Guiding Their Migration to Inflamed Tissues
Immunology, EarlyView.In bone marrow, immature neutrophils express high levels of DEC205, necessary to mediate migration through endothelial cell layers in vitro and in vivo. During maturation and migration to peripheral tissues, expression of DEC205 is downregulated. Thus, expression of DEC205 inversely correlates with the maturation of neutrophils and is involved in ...
Shiying Jin +4 more
wiley +1 more source
Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy. [PDF]
Cells, 2023 Dibas A +7 more
europepmc +1 more source
Granulocyte-macrophage colony-stimulating factor: signals for its mRNA accumulation [PDF]
, 1989 Kenji Yamato +3 more
openalex +1 more source
PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review
Immunology, EarlyView.Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley +1 more source
Molecular physiology of granulocyte-macrophage colony-stimulating factor [PDF]
Blood, 1991 openaire +4 more sources
Mutagenesis of murine granulocyte/macrophage-colony-stimulating factor reveals critical residues near the N terminus [PDF]
, 1987 Nicholas M. Gough +3 more
openalex +1 more source