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Functions of Granulocyte-Macrophage Colony-Stimulating Factor
Critical Reviews in Immunology, 2005GM-CSF was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells. Apart from its physiological role in the control of alveolar macrophage development, it now appears more likely that its major role lies in its ability to govern the properties of the more mature myeloid cells of the ...
Andrew J. Fleetwood +2 more
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The Granulocyte-Macrophage Colony-Stimulating Factors
Science, 1985The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages.
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Clinical Role of Granulocyte-Macrophage Colony-Stimulating Factor
Hematology/Oncology Clinics of North America, 1989The activity of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) for increasing leukocyte production and enhancing mature neutrophil function has been clearly demonstrated in phase I clinical trials in patients with a variety of hematologic and malignant diseases. The focus of current studies includes determination of optimal
Ronald T. Mitsuyasu, David W. Golde
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Granulocyte-Macrophage Colony-Stimulating Factor and Vasculitis
Annals of Internal Medicine, 1989Excerpt To the Editor:Recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) is now being widely used in clinical trials.
Joan H. Schiller +2 more
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Granulocyte Macrophage—Colony Stimulating Factor and Oral Mucositis
Annals of Pharmacotherapy, 2002OBJECTIVE: To evaluate the effect of granulocyte macrophage—colony stimulating factor (GM-CSF) in patients with oral mucositis. DATA SOURCES: Literature was accessed through MEDLINE (1966–June 2000) and bibliographic searches. DATA SYNTHESIS: Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed.
Stacey M. Fung, Mary J Ferrill
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NMR assignment of human granulocyte-macrophage colony-stimulating factor [PDF]
Biomolecular NMR Assignments, 2007 Human granulocyte-macrophage colony-stimulating factor (hGM-CSF), also known as sargramostim or molgramostin, is a cytokine that functions as a hematopoietic cell growth factor. Here we report a near complete assignment for the backbone and side chain resonances for the mature polypeptide.
Yves Aubin +2 more
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Granulocyte-Macrophage Colony-Stimulating Factor for Cancer Treatment
Oncology, 1994In the 5 years since granulocyte-macrophage colony-stimulating factor (GM-CSF) was first tested clinically, a number of different strategies for its use have been evaluated in patients with malignant disease. These include using GM-CSF to support standard and high-dose chemotherapy, to accelerate myeloid reconstitution following marrow transplantation,
Graham J. Lieschke, Jonathan Cebon
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Effect of surgery on granulocyte/macrophage colony‐stimulating factor
Journal of Surgical Oncology, 1978AbstractEighteen surgical patients were studied to determine the effect of anesthesia (general or spinal) and surgery on serum and urinary colony‐stimulating factor(s) (CSF). CSF is a leukopoietin that stimulates proliferation of macrophages and granulocytes from bone marrow precursor cells.
Roger S. Foster, Howard D. Reines
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The Granulocyte-Macrophage Colony-Stimulating Factors [PDF]
, 1986 Haemopoiesis is the process whereby a small population of multipotential stem cells continuously gives rise to a large number of mature blood cells which comprise eight distinct cellular lineages. In normal health, the circulating levels of mature cells are remarkably invariant, suggesting that their production is tightly regulated.
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Granulocyte-macrophage colony-stimulating factor activity in cerebrospinal fluid
Acta Neurologica Scandinavica, 2009The purpose of this study was to analyse the presence of the granulocyte-macrophage colony-stimulating factor (GM-CSF) in human cerebrospinal fluid (SF) of patients affected by multiple sclerosis (MS) in comparison with non-inflammatory neurological diseases.All SFs were collected from 59 patients for diagnostic purpose.
LEONARDI A. +9 more
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