Results 81 to 90 of about 125,553 (184)

Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk

Cells
Thousands struggle with acute and chronic intestinal injury due to various causes. Epithelial intestinal healing is dependent on phenotypic transitions to a mobile phenotype.
Nicholas D. Brown, Emilie E. Vomhof-DeKrey   +1 more
doaj   +1 more source

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Haematologica, 2012
Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor.
Charles B. Goodwin, Zhenyun Yang, Fuqin Yin, Menggang Yu, Rebecca J. Chan   +4 more
doaj   +1 more source

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]

, 2017
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo, Andrey Loboda, Ashani T. Weeraratna, Ayumi Hashimoto, Brian Nam, Butowski, Carus, Challacombe, Chao, Charles Mulligan, Chunsheng Zhang, Condamine, Conway, Coussens, David W. Speicher, DeNardo, Dmitry I. Gabrilovich, Douglas Marvel, Ellen Puré, Fang Wang, Fearon, Feig, Finke, Fred Denstman, Gabrilovich, Gabrilovich, Gascard, Genovese, Gentles, Greenberg, Grivennikov, Guleria, Huang, Kato, Kumar, Ladanyi, Laxminarasimha Donthireddy, Lin, Linda A. Snyder, Lo, Lokeshwar, Lucas, Lucia R. Languino, MacDonald, Manuel A. Sepulveda, Mao, Marlee A. Goins, Messmer, Meyer, Mishra, Mitchem, Mok, Mok, Neil Hockstein, Newman, Noman, Obermajer, Ohno, Orimo, Peter Ordentlich, Pixley, Prashanthi Vonteddu, Pyonteck, Qin Liu, Ramachandran, Reeti Behera, Ries, Ries, Robert H. Vonderheide, Sasse, Sergio Lavilla-Alonso, Shanti Shakamuri, Sionov, Sluijter, Solito, Strachan, Szkandera, Talmadge, Tap, Thomas Condamine, Timothy Chao, Vetsika, Vinit Kumar, Wang, Weber, Xiaowei Xu, Xu, Yang, Zhang, Zhang, Zhu   +90 more
core   +2 more sources

Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal pancytopenia through in vitro culture of bone marrow biopsies [PDF]

, 2012
Background Bovine neonatal pancytopenia (BNP) is a syndrome characterised by thrombocytopenia associated with marked bone marrow destruction in calves, widely reported since 2007 in several European countries and since 2011 in New Zealand. The disease is
Ballingall, Keith T, Bell, Charlotte, Connelly, Maira, Dagleish, Mark P, Laming, Eleanor, Melzi, Eleonora, Rocchi, Mara S, Scholes, Sandra F E, Willoughby, Kim   +8 more
core   +2 more sources

The Role of Granulocyte-macrophage Colony Stimulating Factor in Recurrent Pregnancy Losses

Bagcilar Medical Bulletin, 2019
Objective:A specific factor cannot be detected in approximately half of recurrent pregnancy losses (RPL). The aim of the present study was to investigate the role of a cytokine, granulocyte-macrophage colony stimulating factor (GM-CSF), in the etiology ...
Özlem Karabay Akgül, Emre Volkan Kasımoğulları, Hakan Güraslan, Cemil Akgül   +3 more
doaj   +1 more source

The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages

Brazilian Journal of Pharmaceutical Sciences
It is well established that protein malnutrition (PM) impairs immune defenses and increases susceptibility to infection. Macrophages are cells that play a central role in innate immunity, constituting one of the first barriers against infections ...
Dalila Cunha de Oliveira, Araceli Aparecida Hastreiter, Primavera Borelli, Ricardo Ambrósio Fock   +3 more
doaj   +1 more source

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]

, 2017
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
core   +3 more sources

Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer

Data in Brief, 2017
Granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are cytokines of particular interest in oncology from the perspective of neutropenia management (Mehta et al., 2015 [1]) and also as indirect ...
Zachary A.P. Wintrob, Jeffrey P. Hammel, George K. Nimako, Dan P. Gaile, Alan Forrest, Alice C. Ceacareanu   +5 more
doaj   +1 more source

A Randomised, Blinded, Placebo-Controlled, Dose Escalation Study of the Tolerability and Efficacy of Filgrastim for Haemopoietic Stem Cell Mobilisation in Patients With Severe Active Rheumatoid Arthritis [PDF]

, 1998
Autologous haemopoietic stem cell transplantation (HSCT) represents a potential therapy for severe rheumatoid arthritis (RA). As a prelude to clinical trails, the safety and efficacy of haemopoietic stem cell (HSC) mobilisation required investigation as ...
Biggs, J. C., Brooks, P. M., Fuller, A., Milliken, S. T., Passuello, F., Renwick, J., Snowden, J. A., Staniforth, D.   +7 more
core   +1 more source

Idiotype protein vaccination in combination with adjuvant cytokines in patients with multiple myeloma - evaluation of T-cell responses by different read-out systems

Haematologica, 2007
Anti-idiotypic T cells were analyzed in myeloma patients (n=18) vaccinated with idiotypic protein together with the adjuvant cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) and/or interleukin-12 (IL-12).
Amir Osman Abdalla, Lotta Hansson, Ingrid Eriksson, Barbro Näsman-Glaser, Eva D. Rossmann, Hodjattallah Rabbani, Håkan Mellstedt, Anders Österborg   +7 more
doaj   +1 more source